General
Preferred name
CYTOCHALASIN B
Synonyms
Phomin ()
Preverex ()
P&D ID
PD003482
CAS
14930-96-2
11032-95-4
Tags
natural product
drug candidate
available
Drug indication
Artery stenosis
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Isolated from the fungus Helminthosporium dematioideum.
(GtoPdb)
DESCRIPTION
inhibitor of actin polymerization
(Informer Set)
DESCRIPTION
Potent NLRP3 inflammasome inhibitor; inhibits IL-1beta production
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
9
Organisms
0
Compound Sets
11
Cayman Chemical Bioactives
Drug Repurposing Hub
DrugBank
DrugMAP
Guide to Pharmacology
Informer Set
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
479.27
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
1
cLogP
3.49
TPSA
95.86
Fraction CSP3
0.52
Chiral centers
8.0
Largest ring
14.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Compound status
probe
Primary Target
Actin
MOA
Inhibitor
microtubule inhibitor
Member status
member
Target
ACTB
Arp2/3 complex
Pathway
cytoskeleton
Source data
