General
Preferred name
PLX-4720
Synonyms
PLX4720 ()
PLX 4720 ()
P&D ID
PD003519
CAS
918505-84-7
Tags
available
probe
drug candidate
Drug indication
Cutaneous melanoma
Drug Status
experimental
Probe info
Probe selectivity
protein-selective
Probe type
calculated probe
Probe sources
Probe Miner (suitable probes)
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PLX-4720 is a selective inhibitor of BRAF. (GtoPdb)
DESCRIPTION inhibitor of BRAF (Informer Set)
DESCRIPTION PLX4720 is a 7-azaindole derivative that inhibits B-Raf(V600E) with an IC(50) of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-Raf(V600E) kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. (BOC Sciences Bioactive Compounds)
Cell lines
248
Organisms
0
Compound Sets
23
AdooQ Bioactive Compound Library
A10002
Axon Medchem Screening Library
1474
BOC Sciences Bioactive Compounds
plx4720-cas-918505-84-7-item-100564
Cayman Chemical Bioactives
15142
Concise Guide to Pharmacology 2017/18
5703
Concise Guide to Pharmacology 2019/20
5703
Concise Guide to Pharmacology 2021/22
5703
Concise Guide to Pharmacology 2023/24
5703
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06999
DrugMAP
DMBK9AM
EU-OPENSCREEN Bioactive Compound Library
EOS101249
EUbOPEN Chemogenomics Library
EUB0000597
Guide to Pharmacology
5703
Informer Set
606256
LINCS compound set
10049-999
10049-101
MedChem Express Bioactive Compound Library
HY-51424
Probe Miner (suitable probes)
Q13163/1825384
Selleckchem Bioactive Compound Library
PLX-4720
TargetMol Bioactive Compound Library
T2473
Welcome Trust Cancer Drugs
1371
1036
ZINC Tool Compounds
ZINC000039059267
External IDs
25
Properties
(calculated by RDKit )
Molecular Weight
413.04
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.88
TPSA
91.92
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
BRAF
b-RAF
B-Raf (V600E)
C-Raf-1 (Y340D/Y341D)
BRAF, KDR
B-Raf inhibitor
Compound status
probe
Pathway
ERK MAPK signaling
MAPK
MAPK/ERK Pathway
MOA
Raf
Raf inhibitor
Recommended Cell Concentration
None
Source data