General
Preferred name
KU-0060648
Synonyms
KU 0060648 ()
P&D ID
PD003545
CAS
881375-00-4
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
KU-0060648 is a dual inhibitor of DNA dependent protein kinase (DNA-PK) and the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) α, β and δ subunits. This compound is an analogue of with improved solubility and potency, and additional activity against PI3Ks . This is compound 39 in Cano et al. (2013) .
(GtoPdb)
DESCRIPTION
inhibitor of DNA-dependent protein kinase
(Informer Set)
DESCRIPTION
Selective MEK5 and ERK5 inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
KU-0060648 is a dual inhibitor of DNA-PK (IC50=8.6 nM) and PI3Kα (IC50=4 nM), PI3Kβ (IC50=0.5 nM), PI3Kδ (IC50=0.1 nM) less inhibition of PI3Kγ with IC50 of 0.59 μM.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
DrugMAP
Guide to Pharmacology
Informer Set
MedChem Express Bioactive Compound Library
Other bioactive compounds
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Molecular Weight
582.23
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
7
Aromatic Ring Count
5
cLogP
5.24
TPSA
78.26
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.29
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PRKDC
DNA-PK inhibitor
DNA-PK
MTOR
PI3K
Compound status
probe
Primary Target
DNA-Dependent Protein Kinase
MOA
Inhibitor
Pathway
Cell Cycle/DNA Damage
PI3K/Akt/mTOR
Source data
