General
Preferred name
nutlin-3
Synonyms
Nutlin 3 ()
Nutlin3 ()
P&D ID
PD003703
CAS
548472-68-0
890090-75-2
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION inhibitor of p53-MDM2 interaction (Informer Set)
Cell lines
7
Organisms
1
Compound Sets
6
AdooQ Bioactive Compound Library
A10657
CZ-OPENSCREEN Bioactive Library
DrugMAP
DM5KXFI
Informer Set
411722
Selleckchem Bioactive Compound Library
Nutlin-3
TargetMol Bioactive Compound Library
T2158
External IDs
21
Properties
(calculated by RDKit )
Molecular Weight
580.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
5
Aromatic Ring Count
3
cLogP
5.89
TPSA
83.47
Fraction CSP3
0.3
Chiral centers
2.0
Largest ring
6.0
QED
0.39
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Target
MDM2
p53-MDM2
E3 Ligase ,MDM2/MDMX
Compound status
clinical
Pathway
Apoptosis
Source data