General
Preferred name
H-89
Synonyms
H 89 dihydrochloride ()
Protein kinase inhibitor H-89 ()
H89 ()
H-89 DIHYDROCHLORIDE ()
Protein kinase inhibitor H-89 dihydrochloride ()
5-Isoquinolinesulfonamide ()
H 89 2HCl ()
H-89 (dihydrochloride) ()
H 89 ()
P&D ID
PD005269
CAS
130964-39-5
127243-85-0
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
experimental
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION H-89 is an inhibitor of protein kinase A (PKA) . (GtoPdb)
DESCRIPTION Akt/PKB inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Protein kinase A inhibitor (Tocriscreen Plus)
DESCRIPTION Protein kinase A inhibitor (Tocriscreen Total)
DESCRIPTION Selective inhibitor of Protein Kinase A (cyclic AMP-dependeant Protein Kinase) with an inhibitory constant of 0.0048 uM. (BOC Sciences Bioactive Compounds)
Cell lines
4
Organisms
1
Compound Sets
18
AdooQ Bioactive Compound Library
A11935
BOC Sciences Bioactive Compounds
h-89-cas-127243-85-0-350635
Cayman Chemical Bioactives
10010556
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB07995
DrugMAP
DM4RVGO
EU-OPENSCREEN Bioactive Compound Library
EOS101763
Guide to Pharmacology
5983
LINCS compound set
10411-102
MedChem Express Bioactive Compound Library
HY-15979A
HY-15979
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
H-89-dihydrochloride
TargetMol Bioactive Compound Library
T6250
Tocris Bioactive Compound Library
2910
Tocriscreen Plus
2910
Tocriscreen Total
ZINC Tool Compounds
ZINC000002043204
External IDs
41
Properties
(calculated by RDKit )
Molecular Weight
445.05
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
3
cLogP
3.58
TPSA
71.09
Fraction CSP3
0.15
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Pathway
Protein Tyrosine Kinase/RTK
GPCR/G protein
PI3K/Akt/mTOR signaling
MAPK
Autophagy
Stem Cell/Wnt
TGF-beta/Smad
Target
PKA
S6K1
GSG2, PKIA, PRKACA
Autophagy,PKA,PKG,S6 Kinase
Primary Target
Protein Kinase A
MOA
S6 Kinase
Inhibitor
cAMP-Dependent Protein Kinase (PKA) Inhibitors
Protein Kinase B (PKB/Akt) Inhibitors
Voltage-Gated K(V) Channel Blockers
PKA inhibitor
Member status
member
Source data