General
Preferred name
SPERMIDINE
Synonyms
SPERMIDINE TRIHYDROCHLORIDE ()
N-(4-Aminobutyl)-1,3-diaminopropane ()
N-(3-Aminopropyl)-1,4-diaminobutane ()
Spermidine hydrochloride ()
Spermidine (hydrochloride) ()
4-Azaoctamethylenediamine trihydrochloride ()
Spermidine-d6 ()
P&D ID
PD006808
CAS
334-50-9
124-20-9
1122077-27-3
2514812-10-1
Tags
available
drug candidate
Drug indication
Plaque psoriasis
Rheumatoid arthritis
Drug Status
experimental
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Binds to the polyamine modulatory site of the NMDA glutamate receptor (LOPAC library)
DESCRIPTION Agonist at polyamine site (Tocriscreen Total)
DESCRIPTION Spermidine trihydrochloride is a polyamine that binds to NMDA receptor. Spermidine has been described as an agonist for its ability to enhance the binding of [3H]-MK801. It also acts as a NOS1 inhibitor. (BOC Sciences Bioactive Compounds)
Cell lines
3
Organisms
0
Compound Sets
21
BOC Sciences Bioactive Compounds
spermidine-trihydrochloride-cas-334-50-9-item-17260
Cayman Chemical Bioactives
14918
34697
ChEMBL Drugs
CHEMBL19612
Concise Guide to Pharmacology 2017/18
2390
Concise Guide to Pharmacology 2019/20
2390
Concise Guide to Pharmacology 2021/22
2390
Concise Guide to Pharmacology 2023/24
2390
Drug Repurposing Hub
DrugBank
DB03566
DrugMAP
DMVJNFI
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS101024
Guide to Pharmacology
2390
Ki Database
Spermidine
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1776A
HY-B1776
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
spermidine-trihydrochloride
spermidine
TargetMol Bioactive Compound Library
T4893
The Spectrum Collection
Tocriscreen Total
External IDs
56
Properties
(calculated by RDKit )
Molecular Weight
145.16
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.34
TPSA
64.07
Fraction CSP3
1.0
Chiral centers
0.0
Largest ring
0.0
QED
0.43
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NMDA-Polyamine
Pathway
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Target
Human Endogenous Metabolite
NMDA Receptor
KCNJ4, TXNRD1
Autophagy,NMDAR
MOA
NMDAR
Autophagy
Endogenous Metabolite
Protein tyrosine phophatase N-like stimulator
Drugs Acting on NMDA Receptors
glutamate receptor modulator
Member status
member
Source data