General
Preferred name
BERBERINE
Synonyms
BERBERINE CHLORIDE ()
Berberine tannate ()
BERBERINE SULFATE ()
Umbellatine Sulfate ()
Umbellatine ()
Berberin ()
Natural Yellow 18 ()
Benzodioxide ()
Berberine hydrogen sulphate ()
Berberine hydrochloride ()
Berberine HCl ()
Natural Yellow 18 (chloride hydrate) ()
Natural Yellow 18 (chloride) ()
Natural Yellow 18 (sulfate) ()
Berberine (chloride hydrate) ()
Berberine (chloride) ()
Berberine (sulfate) ()
Berberine chloride (NSC 646666) ()
Berberine chloride hydrate ()
Natural Yellow 18 chloride ()
Berberine-d6 (chloride) ()
NSC-163088 ()
NSC-646666 ()
GNF-Pf-4545 ()
Berberinum ()
Umbellatin ()
Majarine ()
Berbericine ()
Berberone ()
Thalsine ()
Erben ()
NSC-5355 ()
Berberine sulfate anhydrous ()
Berberine sulfate (2:1) ()
Neutral berberine sulfate ()
Berberine sulphate ()
P&D ID
PD006954
CAS
2086-83-1
633-66-9
68030-18-2
633-65-8
141433-60-5
Tags
natural product
drug
drug candidate
nuisance
available
Drug Status
investigational
approved
Max Phase
1.0
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Berberine is a botanical alkaloid compound that has found use in traditional medicine in some countries. It is poorly orally bioavailable and interacts adversely with prescription drugs.
(GtoPdb)
DESCRIPTION
The plant-based alkaloid berberine has potential therapeutic applications for breast cancer, although a better understanding of the genes and cellular pathways regulated by this compound is needed to define the mechanism of its action in cancer treatment. In this review, the molecular targets of berberine in various cancers, particularly breast cancer, are discussed. Berberine was shown to be effective in inhibiting cell proliferation and promoting apoptosis in various cancerous cells. Some signaling pathways affected by berberine, including the MAP (mitogen-activated protein) kinase and Wnt/β-catenin pathways, are critical for reducing cellular migration and sensitivity to various growth factors. Treatment with BBR(Berberine) in rats on the atherogenic diet reduced plasma total cholesterol and nonHDL cholesterol levels by 29%-33% and 31%-41%, respectively, with no significant differences being observed among the three doses. Berberine induced both apoptotic and autophagic death of HepG2 cells, which was associated with a significant activation of AMPK and an increased expression of the inactive form of acetyl-CoA carboxylase (ACC). Berberine did not show major effects on viability of HEK-293 embryonic kidney and HCT116 colon carcinoma cells and was not toxic in concentrations up to 20 μM. Berberine inhibited β-catenin transcriptional activity and attenuated anchorage-independent growth. As a result of berberine treatment, cellular levels of active β-catenin were reduced concomitant with an increase in the expression of E-cadherin.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
35
Organisms
10
Compound Sets
23
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
NIH Mechanistic Set
NPC Screening Collection
Nuisance compounds in cellular assays
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
86
Molecular Weight
336.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
5
Aromatic Ring Count
3
cLogP
3.1
TPSA
40.8
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.67
Structural alerts
1
Nonspecific/NOS
IMP
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
NF-¦ÊB
Microbiology&virology
Stem Cell/Wnt
Protein Tyrosine Kinase/RTK
Cell Cycle/DNA Damage
Anti-infection
Metabolic Enzyme/Protease
Immunology/Inflammation
NF-κB
Apoptosis
MAPK/ERK Pathway
PI3K/Akt/mTOR
Target
Antibacterial
antibiotic
??catenin
Wnt
ROS
Topoisomerase
Bacterial
Autophagy
Reactive Oxygen Species
LDLR
Endogenous Metabolite
Parasite
Akt
AP-1
Caspase
JNK
PI3K
Anti-infection,Apoptosis related,Autophagy,Bcl-2,Caspase,IAP,JNK,p38 MAPK,P450 (e.g. CYP17),PARP,ROS,Topoisomerase
MOA
LDL receptor activator
Source data
