General
Preferred name
Pimagedine
Synonyms
PIMAGEDINE HYDROCHLORIDE ()
AMINOGUANIDINE SULFATE ()
AMINOGUANIDINE HYDROCHLORIDE ()
AMINOGUANIDINE HEMISULFATE ()
CP-12009-18 tartrate ()
Guanyl hydrazine ()
Hydrazinecarboximidamide ()
Imino semicarbazide ()
aminoguanidine ()
GER-11 ()
Aminoguanidinium chloride ()
Pimagedine HCl ()
Aminoguanidine (hydrochloride) ()
Pimagedine, Guanyl hydrazine, Hydrazinecarboximidamide, Imino semicarbazide, Monoaminoguanidine ()
Aminoguanidine HCl ()
NSC-760398 ()
Pimagedina ()
Aminoguanidine ()
P&D ID
PD007889
CAS
1937-19-5
996-19-0
79-17-4
16139-18-7
1068-42-4
2834-84-6
146396-79-4
Tags
available
drug candidate
Drug indication
Diabetic retinopathy
Inhibitor (advanced glycosylation end-product formation)
Diabetic kidney disease
Insulin-resistant disorder
Rheumatoid arthritis
Drug Status
investigational
Max Phase
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Inhibits inducible and constitutive NOS (LOPAC library)
DESCRIPTION Irreversible iNOS inhibitor (Tocriscreen Total)
DESCRIPTION Aminoguanidine hydrochloride is the hydrochloride salt form of Aminoguanidine. Aminoguanidine is an inhibitor that has an irreversible function on iNOS with selectivity against eNOS and nNOS. IC50: iNOS= 5.4 µM; rat nNOS= 160 µM. (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective nitric oxide synthase inhibitor (LOPAC library)
Cell lines
1
Organisms
1
Compound Sets
22
BOC Sciences Bioactive Compounds
aminoguanidine-hydrochloride-cas-1937-19-5-341164
Cayman Chemical Bioactives
81530
ChEMBL Drugs
CHEMBL1256292
CHEMBL225304
Concise Guide to Pharmacology 2017/18
5135
Concise Guide to Pharmacology 2019/20
5135
Concise Guide to Pharmacology 2021/22
5135
Concise Guide to Pharmacology 2023/24
5135
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB05383
DrugMAP
DMPWH30
DMJQDUC
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100593
Guide to Pharmacology
5135
Ki Database
Aminoguanidine
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1041
ReFrame library
Selleckchem Bioactive Compound Library
aminoguanidine-hydrochloride
TargetMol Bioactive Compound Library
T0358
The Spectrum Collection
Tocriscreen Total
External IDs
103
Properties
(calculated by RDKit )
Molecular Weight
74.06
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
4
Rotatable Bonds
0
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.66
TPSA
87.92
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
0.0
QED
0.12
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NOS
Pathway
Immunology/Inflammation
Apoptosis
Target
Inos
AKR1B1, NOS2, TIMP3
NO Synthase
MOA
nitric oxide synthase inhibitor
Solubility
Soluble to > 43 mg/mL in H2O
Source data