General
Preferred name
afamelanotide
Synonyms
Scenesse ()
MT-I ()
[Nle4,D-Phe7]-α-MSH ()
NDP-alpha-MSH ()
Melanotan I ()
[Nle4,D-Phe7]-α-MSH trifluoroacetate salt ()
CUV-1647 ()
(nle4,d-phe7)-.alpha.-msh ()
Melanotan-1 ()
Melanotan ()
CUV1647 ()
Afamelanotida ()
Afamelanotide triacetate ()
A-melanotropin, 4(nle)-7(d-phe) ()
CUV1647 ACETATE ()
AFAMELANOTIDE ACETATE ()
[Nle4,D-Phe7]-?-MSH (trifluoroacetate salt) ()
P&D ID
PD008677
CAS
1566590-77-9
75921-69-6
Tags
available
drug
Drug indication
Discovery agent
Erythropoietic porphyrias
Vitiligo
Drug Status
approved
investigational
Max Phase
4.0
First approval
2014
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Synthetic analogue of α-MSH
DESCRIPTION Afamelanotide is a synthetic analogue of α-MSH, and is a first-in-class clinically used non-selective MC receptor agonist. It is used for certain dematological applications . (GtoPdb)
DESCRIPTION [Nle4,D-Phe7]-α-MSH is a synthetic analog of α-melanocyte stimulating hormone (α-MSH). (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
0
Compound Sets
16
BOC Sciences Bioactive Compounds
nle4-d-phe7-msh-trifluoroacetate-salt-292035
Cayman Chemical Bioactives
24475
ChEMBL Approved Drugs
CHEMBL441738
CHEMBL4297213
ChEMBL Drugs
CHEMBL441738
CHEMBL4297213
Drug Repurposing Hub
DrugBank
DB04931
DrugBank Approved Drugs
DB04931
DrugMAP
DMTMHW2
DMVWHTG
DrugMAP Approved Drugs
DMVWHTG
Guide to Pharmacology
1324
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL441738
MedChem Express Bioactive Compound Library
HY-N2466
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
QW68W3J66U
ReFrame library
TargetMol Bioactive Compound Library
T7589
External IDs
42
Properties
(calculated by RDKit )
Molecular Weight
1645.84
Hydrogen Bond Acceptors
21
Hydrogen Bond Donors
23
Rotatable Bonds
50
Ring Count
6
Aromatic Ring Count
5
cLogP
-4.1
TPSA
642.98
Fraction CSP3
0.5
Chiral centers
12.0
Largest ring
6.0
QED
0.01
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
melanocortin-1 receptor
Melanocortin Receptor
MOA
melanocyte-stimulating hormone mimetic
Biosynthetic Origin
Peptide (Ribosomal)
Therapeutic Indication
Phototoxicity in Adults
Therapeutic Class
Hormone Therapy
Pathway
GPCR/G protein
Neuronal Signaling
Source data