General
Preferred name
glutamic acid
Synonyms
Glutamic acid ()
L-GLUTAMATE ()
(+)-L-Glutamic acid ()
(S)-Glutamic acid ()
Glutaminol ()
glutacid ()
Aciglut ()
L-glutamic acid ()
(+)-L-Glutamic acid(S)-Glutamic acid ()
L-2-amino-pentanedioic acid ()
E 620 ()
INS-620 ()
Glutamidex ()
E620 ()
Glutamic acid, l- ()
Acido glutamico ()
E-620 ()
NSC-143503 ()
L-alpha-aminoglutaric acid ()
FEMA NO. 3285 ()
Acide glutamique ()
L-Glutamate ()
INS NO.620 ()
P&D ID
PD008882
CAS
56-86-0
10549-13-0
24938-00-9
Tags
available
drug
Approved by
FDA
Drug indication
Schizophrenia
Drug Status
approved
investigational
nutraceutical
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS In addition to being one of the building blocks in protein synthesis, it is the most widespread neurotransmitter in brain function, as an excitatory neurotransmitter and as a precursor for the synthesis of GABA in GABAergic neurons.;
DESCRIPTION Selective GABAB antagonist; more potent than Saclofen (Cat. No. 0246) (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
1
Compound Sets
21
ChEMBL Drugs
CHEMBL575060
Concise Guide to Pharmacology 2017/18
1369
Concise Guide to Pharmacology 2019/20
1369
Concise Guide to Pharmacology 2021/22
1369
Concise Guide to Pharmacology 2023/24
1369
Drug Repurposing Hub
DrugBank
DB00142
DrugBank Approved Drugs
DB00142
DrugCentral
1310
DrugCentral Approved Drugs
1310
DrugMAP
DM4PUDW
DrugMAP Approved Drugs
DM4PUDW
Guide to Pharmacology
1369
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL575060
MedChem Express Bioactive Compound Library
HY-14608
NPC Screening Collection
Selleckchem Bioactive Compound Library
s-glutamic-acid
TargetMol Bioactive Compound Library
T2A2497
The Spectrum Collection
Tocris Bioactive Compound Library
0218
ZINC Tool Compounds
ZINC000001482113
External IDs
63
Properties
(calculated by RDKit )
Molecular Weight
147.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.74
TPSA
100.62
Fraction CSP3
0.6
Chiral centers
1.0
Largest ring
0.0
QED
0.49
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Apoptosis
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Neuronal Signaling
Target
Endogenous Metabolite
AADAT, AASS, ABAT, ALDH18A1, ASNS, BCAT1, BCAT2, CCBL2, DNPEP, EARS2, ENPEP, EPRS, FOLH1, FPGS, FTCD, GAD1, GAD2, GATB, GCLC, GCLM, GGCX, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM6, GRM7, GRM8, LGSN, NADSYN1, NAGS, OPLAH, PFAS, PGCP, PSAT1, SLC1A1, SLC1A2, SLC1A3, SLC1A6, SLC1A7, SLC25A18, SLC25A22, SLC7A11, TAT
Ferroptosis
iGluR
GluR
Primary Target
Non-selective Metabotropic Glutamate
MOA
Agonist
glutamate receptor agonist
Therapeutic Class
Dietary supplement
Source data