General
Preferred name
TETRACAINE
Synonyms
TETRACAINE HYDROCHLORIDE ()
Amethocaine hydrochloride ()
Tetracaine HCl ()
Amethocalne HCl ()
Tetracaďne hydrochloride ()
Tetracaïne hydrochloride ()
Tetracaďne hydrochloride ()
tetracaine, MicroParticle ()
Butethanol ()
Anethaine ()
Pantocaine ()
Tetracaini hydrochloridum ()
Dicainum ()
Tetraca ()
Curtacain ()
Tetocaine ()
NSC-757337 ()
Locan ()
Menonasal ()
Amethocaine ()
Ametop ()
Pontocaine ()
Dicaine ()
P&D ID
PD009137
CAS
136-47-0
94-24-6
100311-22-6
Tags
available
natural product
drug
Approved by
FDA
First approval
2005
2016
Drug indication
Pain
Anesthetic (local)
Anesthetic (local),Anesthetic (topical)
Spinal anesthesia
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic.; ; The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.
DESCRIPTION Local anesthetic (LOPAC library)
DESCRIPTION Tetracaine is a topical local anesthetic for the eyes. It works by interfering with entry of sodium ions into nerve cells. It is also used in assessing the potential for drug-nanoparticle surface interactions to improve drug penetration into the skin. It has been listed. (BOC Sciences Bioactive Compounds)
Compound Sets
25
BOC Sciences Bioactive Compounds
tetracaine-cas-94-24-6-item-79918
Cayman Chemical Bioactives
30059
ChEMBL Approved Drugs
CHEMBL1255654
CHEMBL698
ChEMBL Drugs
CHEMBL1255654
CHEMBL698
Drug Repurposing Hub
DrugBank
DB09085
DrugBank Approved Drugs
DB09085
DrugCentral
2610
DrugCentral Approved Drugs
2610
DrugMAP
DM9J6C2
DrugMAP Approved Drugs
DM9J6C2
DrugMatrix
EU-OPENSCREEN Bioactive Compound Library
EOS100324
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL698
Mcule NIBR MoA Box Subset
MCULE-8973928579
NCATS Inxight Approved Drugs
0619F35CGV
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
tetracaine-hydrochloride-pontocaine
TargetMol Bioactive Compound Library
T1198
The Spectrum Collection
VGSC-DB
NA0065
NA0066
NA0067
NA0068
NA0069
NA0070
NA0071
NA0072
NA0073
NA0074
NA0075
NA5928
NA5929
NA5930
NA5931
External IDs
56
Properties
(calculated by RDKit )
Molecular Weight
264.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
8
Ring Count
1
Aromatic Ring Count
1
cLogP
2.62
TPSA
41.57
Fraction CSP3
0.53
Chiral centers
0.0
Largest ring
6.0
QED
0.58
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Neuronal Signaling
Membrane Transporter/Ion Channel
Target
Sodium Channel
SCN10A, SCN11A, SCN1A, SCN2A, SCN3A, SCN4A, SCN5A, SCN7A, SCN8A, SCN9A
Calcium Channel
Member status
member
Indication
anesthetic
MOA
membrane integrity inhibitor
Therapeutic Class
Anesthetics
VGSC Target
Nav1.2
Nav1.3
Nav1.5
Nav1.6
Nav1.7
Nav1.9
Solubility
DMSO:43mg/mL
Source data