General
Preferred name
IFENPRODIL
Synonyms
IFENPRODIL TARTRATE ()
Ifenprodil,(+/-) ()
Alpha 1-PI ()
Ifenprodil hemitartrate ()
RC-61-91 ()
NP-120 ()
RC 61-91 ()
Vadilex ()
Ifenprodil (hemitartrate) ()
P&D ID
PD009158
CAS
23210-58-4
23210-56-2
136172-79-7
Tags
available
probe
drug
Drug indication
Cancer related pain
Alpha-1 antitrypsin deficiency
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Probe info
Probe type
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
2
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ifenprodil is an NMDA receptor antagonist and acts at the polyamine site. It is also an α2 adrenergic receptor ligand. It is selective for σ2 ligand over σ1 sites. It is used as a neuroprotective agent and peripheral vasodilator.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Blocks the polyamine binding site associated with the NMDA glutamate receptor; neuroprotective
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
2
Compound Sets
25
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
66
Molecular Weight
325.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
3.77
TPSA
43.7
Fraction CSP3
0.43
Chiral centers
2.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Polyamine site NMDA
Pathway
Neuroscience
Target
NMDA Receptor
NMDAR
MOA
NMDAR antagonist
NMDA Antagonists
alpha-Adrenoceptor Antagonists
Member status
virtual
ATC
C04AX28
Toxicity type
NULL
Source data
