General
Preferred name
TIANEPTINE
Synonyms
Tianeptine sodium ()
Tianeptine sodium salt ()
Jnj-39823277 ()
Tianeptina ()
S-1574 ()
TPI-1062 ()
Gas station heroin ()
Stablon ()
Tianeptine (sodium salt) ()
Tianeptine-d6 (hydrochloride) ()
Tianeptine (sodium salt) (CRM) ()
P&D ID
PD009273
CAS
30123-17-2
66981-73-5
72797-41-2
54317-11-2
1159812-13-1
Tags
available
drug
Drug indication
Major depressive disorder
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
; Analyses in large-scale epidemiologic surveys have shown that the anxiety disorders are widely comorbid with major depression. This makes antidepressant with anxiolytic properties particularly unique and attractive [A31971].; ; Tianeptine is effective in reducing depressive symptoms in mild to severe major depressive disorder and also alleviates anxious symptoms associated with depression without the need for coadministration of an anti-anxiety medication [A31971]. ; ; These findings, however, are met with controversial data. In a study of healthy volunteers, Tianeptine-treated subjects were less accurate at identifying facial expressions, suggesting a lack of improvement in the psychomotor symptoms of depression. The tianeptine group also showed reduced memory and reduced attentional vigilance to various stimuli [A31987].
DESCRIPTION
Chemically tianeptine can be classified as a tricyclic antidepressant (TCA), but evidence suggests that it has a quite different pharmacological mechanism of action compared to typical TCAs .
(GtoPdb)
DESCRIPTION
Potent and selective noradrenalin uptake inhibitor; orally active
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective facilitator of 5-HT uptake; antidepressant
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
17
AdooQ Bioactive Compound Library
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Mcule NIBR MoA Box Subset
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
64
Molecular Weight
436.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
3
Aromatic Ring Count
2
cLogP
4.19
TPSA
86.71
Fraction CSP3
0.38
Chiral centers
1.0
Largest ring
7.0
QED
0.61
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Target
5-HT
Primary Target
5-HT Transporters
Member status
member
MOA
5-HT Reuptake Enhancers
Source data
