General
Preferred name
MIANSERIN
Synonyms
MIANSERIN HYDROCHLORIDE ()
Org GB 94 ()
Mianserin HCl ()
ORG GB-94 HCl ()
MIANSERIN (-) ()
MIANSERIN (+) ()
Mianserine hydrochloride ()
Mianserin (hydrochloride) ()
Bolvidon, Norval, Tolvon,ORG GB-94 HCl,Mianserin hydrochloride ()
NSC-759590 ()
ORG-GB 94 ()
NORVAL ()
TETRAMIDE ()
BOLVIDON ()
J16.389I ()
Mianserine ()
Tolvon ()
Mianserina ()
P&D ID
PD009326
CAS
21535-47-7
24219-97-4
Tags
available
drug
First approval
1976
Drug indication
Antihistaminic
Depression
Serotonin Inhibitor
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION The approved drug mianserin is a racemic mixture of two enantiomers. The structure shown here does not specify stereochemistry and represents the mixture. (GtoPdb)
DESCRIPTION Highly selective D4 antagonist (Tocris Bioactive Compound Library)
DESCRIPTION Serotonin receptor antagonist (LOPAC library)
DESCRIPTION 5-HT2 antagonist. Has moderate affinity for 5-ht6 (Tocriscreen Total)
Cell lines
0
Organisms
2
Compound Sets
32
AdooQ Bioactive Compound Library
A10588
Cayman Chemical Bioactives
39378
ChEMBL Approved Drugs
CHEMBL544428
CHEMBL6437
ChEMBL Drugs
CHEMBL544428
CHEMBL6437
Concise Guide to Pharmacology 2017/18
135
Concise Guide to Pharmacology 2019/20
135
Concise Guide to Pharmacology 2021/22
135
Concise Guide to Pharmacology 2023/24
135
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB06148
DrugBank Approved Drugs
DB06148
DrugCentral
1796
DrugCentral Approved Drugs
1796
DrugMAP
DMVKA4O
DrugMAP Approved Drugs
DMVKA4O
DrugMatrix
EUbOPEN Chemogenomics Library
EUB0000994
Guide to Pharmacology
135
Ki Database
MIANSERIN
MIANSERIN (+)
MIANSERIN (-)
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL6437
MedChem Express Bioactive Compound Library
HY-B0188A
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
mianserin-hydrochloride
TargetMol Bioactive Compound Library
T0783
The Spectrum Collection
Tocris Bioactive Compound Library
0997
Tocriscreen Total
Withdrawn 2.0
w235
External IDs
53
Properties
(calculated by RDKit )
Molecular Weight
264.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
3.08
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
1.0
Largest ring
7.0
QED
0.72
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Histamine Receptor
5-HT
HT
Sert (Sodium-dependent)
Adrenergic Receptor
DA transporter
dopamine
Noradrenaline transporter (Sodium-dependent)??-opioid receptor
ADRA1A, ADRA1B, ADRA1D, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR6, HTR7
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Endocrinology/Hormones
Neuroscience
Primary Target
Non-selective 5-HT2
MOA
Antagonist
serotonin receptor antagonist
Indication
depression
ATC
N06AX03
Toxicity type
hematological
Therapeutic Class
Antidepressants
Recommended Cell Concentration
None
Source data