General
Preferred name
cariprazine
Synonyms
CARIPRAZINE HYDROCHLORIDE ()
RGH-188 ()
RGH188 hydrochloride ()
Cariprazine HCl ()
Cariprazine (hydrochloride) ()
cariprazine hydrochloride, prolonged-release ()
RGH-188 HCL ()
VRAYLAR ()
Reagila ()
MP-214 ()
Fri-7000188 ()
GED-129 ()
Cariprazina ()
Cariprazine-d6 ()
P&D ID
PD009328
CAS
839712-12-8
1083076-69-0
1308278-67-2
Tags
available
drug
Approved by
FDA
First approval
2015
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION Cariprazine is an atypical antipsychotic indicated for the treatment of schizophrenia and for the acute treatment of manic or mixed episodes associated with bipolar I; disorder.
TOXICITY Accidental acute overdosage (48 mg/day) was reported in one patient. This patient experienced orthostasis and sedation. The patient fully recovered the same day.; Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Cariprazine is not approved for the treatment of patients with dementia-related psychosis.
DESCRIPTION Cariprazine is an antipsychotic. Our structure was drawn from the INN record which shows stereo-chemistry for this compound. PubChem have a record only for the non-chiral molecule, with CID 11154555. The compound is liphophilic meaning that it can easily cross the blood-brain barrier, to reach its site of action . (GtoPdb)
Compound Sets
21
Cayman Chemical Bioactives
ChEMBL Approved Drugs
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
Mcule NIBR MoA Box Subset
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
426.2
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
1
cLogP
4.34
TPSA
38.82
Fraction CSP3
0.67
Chiral centers
0.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
D3
D2
5-HT1A
DRD2, DRD3
MOA
Dopamine Receptor
5-HT Receptor
Dopamine D2/3 receptor partial agonist
Dopamine Receptor antagonist
Member status
member
Indication
schizophrenia
Recommended Cell Concentration
None
Source data