General
Preferred name
CELIPROLOL
Synonyms
CELIPROLOL HYDROCHLORIDE ()
Celiprolol HCL ()
Celiprolol (hydrochloride) ()
Celectol ()
NSC-324509 ()
ACER002 ()
ACER-002 ()
Selectol ()
Celiprolol pch ()
Celiprolol (hydrochloride??) ()
P&D ID
PD009361
CAS
57470-78-7
56980-93-9
Tags
available
drug
First approval
1982
Drug indication
Anti-Adrenergic (beta-receptor)
Hypertension
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Celiprolol is a cardioselective β1-adrenoceptor antagonist, but also displays weak partial agonist (sympathomimetic) action at β2-adrenoceptors.
(GtoPdb)
MOA
Celiprolol is a vasoactive beta-1 selective adrenoceptor antagonist with partial beta-2 agonist activity. The beta-2 agonist activity is thought to account for its mild vasodilating properties. It lowers blood pressure in hypertensive patients at rest and on exercise. The effects on heart rate and cardiac output are dependent on the pre-existing background level of sympathetic tone.; Under conditions of stress such as exercise, celiprolol attenuates chronotropic and inotropic responses to sympathetic stimulation. However, at rest minimal impairment of cardiac function is seen.
DESCRIPTION
Celiprolol hydrochloride is a cardioselective β1-adrenergic blocker with potential antianginal and antihypertensive properties.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
18
Axon Medchem Screening Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
48
Molecular Weight
379.25
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
9
Ring Count
1
Aromatic Ring Count
1
cLogP
2.89
TPSA
90.9
Fraction CSP3
0.6
Chiral centers
1.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ß2 antagonist
Adrenergic Receptor
NO Synthase
Pathway
GPCR/G protein
Immunology/Inflammation
Neuronal Signaling
Source data
