General
Preferred name
debrisoquine
Synonyms
DEBRISOQUIN SULFATE ()
Debrisoquin HI ()
Debrisoquine (hydroiodide) ()
Isocaramidine (hydroiodide) ()
Ro 5-3307/1 (hydroiodide) ()
DEBRISOQUIN ()
Debrisoquine sulfate ()
Debrisoquin (hydroiodide) ()
NSC-139330 ()
Debrisoquin sulphate ()
Declinax ()
RO 5-3307/1 ()
Debrisoquin Sulfate ()
Debrisoquine ()
Debrisoquina ()
Debrisoquin (hemisulfate ()
P&D ID
PD009366
CAS
581-88-4
1131-64-2
1052540-65-4
Tags
available
drug
First approval
1965
Drug indication
Antihypertensive
Hypertension
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Antihypertensive; metabolized to tetrahydroisoquinoline (TIQ) which may play a role in the induction of Parkinson's Disease
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
19
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
LOPAC library
MedChem Express Bioactive Compound Library
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
71
Molecular Weight
175.11
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
0.94
TPSA
53.11
Fraction CSP3
0.3
Chiral centers
0.0
Largest ring
6.0
QED
0.46
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
hypertension
Target
SLC6A2
SARS-CoV
Ser/Thr Protease
MOA
adrenergic neuron blocker
Therapeutic Class
Antihypertensive Agents
Pathway
Anti-infection
Metabolic Enzyme/Protease
Source data
