General
Preferred name
Metamfetamine
Synonyms
methamphetamine ()
METHAMPHETAMINE HYDROCHLORIDE ()
Methylamfetamine hydrochloride ()
Methamphetamine hydrochloride cii ()
Methamphetamine hcl ()
NSC-169505 ()
Desoxyn ()
Methampex ()
Metamfetamine hydrochloride ()
Desoxyephedrine hydrochloride ()
NSC-25115 ()
Metanfetamina ()
J6.362B ()
(s)-phenylmethylaminopropane ()
(+)-Methamphetamine (hydrochloride) ()
(+)-Methamphetamine (hydrochloride) (CRM) ()
P&D ID
PD009472
CAS
826-10-8
537-46-2
139-47-9
51-57-0
Tags
available
drug
Approved by
FDA
First approval
1943
Drug indication
Stimulant (central)
Pain
Attention deficit hyperactivity disorder
Drug Status
approved
withdrawn
illicit
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ABSORPTION
Methamphetamine is rapidly absorbed from the gastrointestinal tract with peak methamphetamine concentrations occurring in 3.13 to 6.3 hours post ingestion. Moreover, when administered intranasally or as an inhalation, methamphetamine also demonstrates a high degree of absorption. It is distributed to most parts of the body. Because methamphetamine has a high lipophilicity it is distributed across the blood brain barrier and crosses the placenta.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
LSP-MoA library (Laboratory of Systems Pharmacology)
NPC Screening Collection
Withdrawn 2.0
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
53
Molecular Weight
149.12
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
1
Aromatic Ring Count
1
cLogP
1.84
TPSA
12.03
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
ATC
N06BA03
Toxicity type
multiple
Therapeutic Class
Central Nervous System Stimulants
Source data
