General
Preferred name
COLCHICINE
Synonyms
Colchineos ()
Colchisol ()
Colcin ()
P&D ID
PD009519
CAS
64-86-8
54192-66-4
Tags
natural product
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
ROE In healthy volunteers (n=12) 40 – 65% of 1 mg orally administered colchicine was recovered unchanged in urine.; Enterohepatic recirculation and biliary excretion are also postulated to play a role in colchicine elimination.
DESCRIPTION Inhibitor of protein synthesis. Antileukemic agent (Tocris Bioactive Compound Library)
DESCRIPTION Inhibitor of tubulin (Tocriscreen Total)
Cell lines
1
Organisms
0
Compound Sets
4
DrugMatrix
Enamine BioReference Compounds
Tocris Bioactive Compound Library
1364
Tocriscreen Total
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
399.17
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
2.87
TPSA
83.09
Fraction CSP3
0.36
Chiral centers
1.0
Largest ring
7.0
QED
0.83
Structural alerts
1
Tubulin modulation
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Microtubules
MOA
Microtubule Associated
Pathway
Cytoskeletal Signaling
Target
Microtubule
Source data