General
Preferred name
yohimbine
Synonyms
Yohimbin ()
YOHIMBINE HYDROCHLORIDE ()
Yohimbine HCl ()
Antagonil ()
Yohimbine HCl (Antagonil) ()
Yohimbine (Hydrochloride) ()
Yocon ()
NSC-19509 ()
Prowess Plain ()
Yohimbinum ()
P&D ID
PD009520
CAS
65-19-0
146-48-5
103834-06-6
Tags
natural product
drug
available
Approved by
FDA
Drug indication
Erectile dysfunction
Drug Status
investigational
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Yohimbine exerts actions on many receptors of the dopamine, serotonin and adrenergic families, with highest activity as an antagonist of α2-adrenoceptors. (GtoPdb)
DESCRIPTION alpha2 Adrenoceptor antagonist isolated from Cortnanthe johimbe (LOPAC library)
Cell lines
1
Organisms
4
Compound Sets
27
AdooQ Bioactive Compound Library
A11003
Cayman Chemical Bioactives
19869
ChEMBL Approved Drugs
CHEMBL537669
CHEMBL15245
ChEMBL Drugs
CHEMBL537669
CHEMBL15245
Concise Guide to Pharmacology 2017/18
102
Concise Guide to Pharmacology 2019/20
102
Concise Guide to Pharmacology 2021/22
102
Concise Guide to Pharmacology 2023/24
102
Drug Repurposing Hub
DrugBank
DB01392
DrugBank Approved Drugs
DB01392
DrugCentral
3659
DrugCentral Approved Drugs
3659
DrugMAP
DMJCP1Y
DrugMAP Approved Drugs
DMJCP1Y
Guide to Pharmacology
102
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL537669
CHEMBL15245
Mcule NIBR MoA Box Subset
MCULE-1354974676
MedChem Express Bioactive Compound Library
HY-N0127
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Yohimbine-hydrochloride(Antagonil)
TargetMol Bioactive Compound Library
T2142
ZINC Tool Compounds
ZINC000003860825
External IDs
59
Properties
(calculated by RDKit )
Molecular Weight
354.19
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
2
cLogP
2.65
TPSA
65.56
Fraction CSP3
0.57
Chiral centers
5.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha2
Pathway
GPCR/G protein
Neuronal Signaling
Target
??2 adrenergic receptor
¦Á2-adrenergic receptor
ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR5A, HTR7, KCNJ1, KCNJ10, KCNJ11, KCNJ12, KCNJ14, KCNJ15, KCNJ8
Adrenergic Receptor
Member status
member
MOA
alpha2-Adrenoceptor Antagonists
Adrenergic Receptor antagonist
Indication
cardiac arrythmia, bradycardia
Therapeutic Class
Mydriatics
Source data