General
Preferred name
VECURONIUM
Synonyms
VECURONIUM BROMIDE ()
ORG NC 45 ()
Vecuronium (bromide) ()
ORG NC45 ()
ORG-NC 45 ()
Bromure de vecuronium ()
Pancuronium bromide impurity, vecuronium bromide - ()
Bromuro de vecuronio ()
NSC-759184 ()
Musculax ()
Norcuron ()
Vecuronium ion ()
Vecuronium cation ()
Vecuronium (bromide) ()
P&D ID
PD009547
CAS
86029-43-8
50700-72-6
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
Neuromuscular Blocking Agent
Spasm
Drug Status
approved
investigational
Max Phase
4.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS
The principal pharmacologic effects demonstrated by vecuronium revolve around its competitive binding of cholinergic receptors located at motor end plates. This competitive binding results in muscle relaxant effects that are typically employed as an adjunct to general anesthesia.
INDICATION
Vecuronium is a muscle relaxing agent and is used as an adjunct in general anesthesia.
DESCRIPTION
Approved as vecuronium bromide (PubChem CID 39764).
The neuromuscular blockade induced by vecuronium can be reversed by administering the selective relaxant binding agent (SRBA) sugammadex (PubChem CID 6918584, a.k.a. Bridion®, Org 25969). (GtoPdb)
The neuromuscular blockade induced by vecuronium can be reversed by administering the selective relaxant binding agent (SRBA) sugammadex (PubChem CID 6918584, a.k.a. Bridion®, Org 25969). (GtoPdb)
DESCRIPTION
Vecuronium bromide (Norcuron) is a muscle relaxant in the category of non-depolarizing blocking agents. Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
29
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
Guide to Pharmacology
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
58
Molecular Weight
557.43
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
6
Aromatic Ring Count
0
cLogP
5.97
TPSA
55.84
Fraction CSP3
0.94
Chiral centers
10.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
nicotinic acetylcholine receptor antagonist
AChR
acetylcholine receptor antagonist
Target
Muscle-type nicotinic acetylcholine receptor
nAChR
CHRNA2
Pathway
Neuroscience
Membrane Transporter/Ion Channel
Neuronal Signaling
Indication
muscle relaxant
Therapeutic Class
Analgesics
Source data
