General
Preferred name
buprenorphine
Synonyms
Buprenorphine Hydrochloride ()
Buprenorphine (hydrochloride) ()
P&D ID
PD009640
CAS
52485-79-7
53152-21-9
Tags
biased GPCR ligand
natural product
drug
available
Approved by
FDA
EMA
First approval
1981
Drug indication
Pain
Psychiatric disorder
Migraine
Drug Status
illicit
vet_approved
approved
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Buprenorphine is a more potent and longer lasting analgesic than . It is a semisynthetic derivative of thebaine (paramorphine).
(GtoPdb)
HALF-LIFE
IV administration, 0.3 mg = 1.2 - 7.2 hours (mean 2.2 hours);; Sublingual administration = 37 hours.
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
15
BiasDB
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
NCATS Inxight Approved Drugs
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
35
Molecular Weight
467.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
8
Aromatic Ring Count
1
cLogP
4.41
TPSA
62.16
Fraction CSP3
0.79
Chiral centers
7.0
Largest ring
6.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Therapeutic Class
Analgesics
Source data
