General
Preferred name
LOPERAMIDE
Synonyms
LOPERAMIDE HYDROCHLORIDE ()
R-18553 ()
R-18553 (hydrochloride) ()
Loperamide HCl ()
ADL 2-1294 ()
R-18553 (hydrochloride)Loperamide HCl ()
Loperamide HCl ()
Loperamide (hydrochloride) ()
ADL 2-1294,R-18553 hydrochloride ()
Entrocalm ()
Diareze ()
Imodium IBS Relief ()
Lodiar ()
Imodium A-D ()
Diaquitte ()
Loperamidi hydrochloridum ()
Imodium LiquiCaps ()
NSC-696356 ()
Normaloe ()
Diarrhoea Relief ()
Imodium Classic ()
R 18,553 ()
Diah-Limit ()
Imodium ()
Diocalm ()
Imodium A-D Ez Chews ()
Arret ()
Imodium Advanced ()
Dioraleze ()
Loperagen ()
Imodium Instant Melts ()
Gppe Pack ()
Diasorb ()
Imodium Instants ()
Norimode ()
Diocaps ()
ARRET ()
DIAH-LIMIT ()
DIAQUITTE ()
DIAREZE ()
DIARRHOEA RELIEF ()
DIASORB ()
DIOCALM ()
DIOCAPS ()
DIORALEZE ()
ENTROCALM ()
GPPE PACK ()
IMODIUM ()
IMODIUM A-D ()
IMODIUM A-D EZ CHEWS ()
IMODIUM CLASSIC ()
IMODIUM IBS RELIEF ()
IMODIUM INSTANT MELTS ()
IMODIUM INSTANTS ()
IMODIUM LIQUICAPS ()
Imodium advanced ()
LODIAR ()
LOPERAGEN ()
LOPERAMIDI HYDROCHLORIDUM ()
NORIMODE ()
NORMALOE ()
P&D ID
PD009698
CAS
34552-83-5
53179-11-6
137524-29-9
Tags
biased GPCR ligand
natural product
drug
available
Approved by
FDA
First approval
1976
Drug indication
Antiperistaltic
Diarrhea
Drug Status
withdrawn
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Loperamide is an opioid-receptor agonist used as an anti-diarrheal agent. Although unreported previously, recent clinical cases of severe cardiotoxicity (and death) due to high-dose loperamide abuse have been reported . (GtoPdb)
DESCRIPTION Meperidine congener which binds to opioid receptors; Ca2+ channel antagonist (LOPAC library)
DESCRIPTION Peripherally acting μ agonist. Also Ca2+ channel blocker (Tocriscreen Total)
DESCRIPTION Muscarinic agonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
8
Compound Sets
41
BiasDB
Loperamide
Cayman Chemical Bioactives
14875
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1707
CHEMBL841
ChEMBL Drugs
CHEMBL1707
CHEMBL841
Concise Guide to Pharmacology 2017/18
7215
Concise Guide to Pharmacology 2019/20
7215
Concise Guide to Pharmacology 2021/22
7215
Concise Guide to Pharmacology 2023/24
7215
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00836
DrugBank Approved Drugs
DB00836
DrugCentral
1599
DrugCentral Approved Drugs
1599
DrugMAP
DMOJZQ9
DrugMAP Approved Drugs
DMOJZQ9
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101675
EUbOPEN Chemogenomics Library
Guide to Pharmacology
7215
JUMP-Target 1 Compound Set
3955
Ki Database
Loperamide
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1707
CHEMBL841
Mcule NIBR MoA Box Subset
MCULE-3957783776
MedChem Express Bioactive Compound Library
HY-B0418A
NCATS Inxight Approved Drugs
77TI35393C
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Loperamide-hydrochloride
TargetMol Bioactive Compound Library
T0209
The Spectrum Collection
Tocris Bioactive Compound Library
0840
Tocriscreen Total
Withdrawn 2.0
w117
ZINC Tool Compounds
ZINC000000537928
External IDs
61
Properties
(calculated by RDKit )
Molecular Weight
476.22
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
3
cLogP
5.09
TPSA
43.78
Fraction CSP3
0.34
Chiral centers
0.0
Largest ring
6.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Opioid Receptor agonist
Agonist
mu-Opioid Agonists
Target
Mu opioid receptor
??-opioid receptor
CACNA1A, CALM1, OPRD1, OPRK1, OPRM1, POMC
OPRM1
Opioid Receptor
Autophagy,Opioid Receptor
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Autophagy
Neuronal Signaling
Primary Target
? Opioid Receptors
Member status
member
Indication
diarrhea
ATC
A07DA03
Toxicity type
gastrointestinal
Therapeutic Class
Antidiarrheals
Recommended Cell Concentration
None
Source data