General
Preferred name
perindopril
Synonyms
PERINDOPRIL ERBUMINE ()
Perindopril tert-butylamine salt ()
S9490-3 ()
Perindopril Erbumine (Aceon) ()
PERINDOPRIL ARGININE ()
S-9490 ()
Perindopril (tert-butylamine salt) ()
S-9490 (erbumine) ()
IC980033 ()
Perindopril (erbumine) ()
NSC-758929 ()
Aceon ()
S-9490-3 ()
Perindopril tert-butylamine ()
McN-A-2833-109 ()
Coversyl ()
McN-A-2833 ()
P&D ID
PD009719
CAS
107133-36-8
82834-16-0
99149-83-4
Tags
available
drug candidate
drug
prodrug
Approved by
FDA
First approval
1993
2015
Drug indication
Discovery agent
Antihypertensive
Hypertension
Antihypertensive,Enzyme Inhibitor (angiotensin-converting)
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Prodrug metabolically converted to the drug perindoprilat. Perindopril erbumine [USAN] aka perindopril tert-butylamine, is PubChem CID 441313. (GtoPdb)
DESCRIPTION Soluble guanylyl cyclase (sGC) activator; induces G1 cell cycle arrest (Tocris Bioactive Compound Library)
DESCRIPTION Perindopril is a long-acting ACE inhibitor. It is used to treat patients with hypertension, diabetes mellitus type 2, coronary heart disease, chronic heart failure or stable coronary artery disease in form of perindopril arginine on the basis of a large evidence. lt has anticancer activity through the inhibition of tumor growth and angiogenesis in hepatocellular carcinoma cells. It suppresses angiotensin II production in vitro. In the in vitro cell proliferation assays, it does not show significant effect on the cell proliferation. In vivo assays demonstrate it can suppress the growth of SCC-VII cells. It is reported that 8 mg perindopril given orally can lower blood pressure without a change in heart rate. It was developed by Xoma. (BOC Sciences Bioactive Compounds)
Compound Sets
22
AdooQ Bioactive Compound Library
A10710
BOC Sciences Bioactive Compounds
perindopril-cas-82834-16-0-99051
Cayman Chemical Bioactives
20796
ChEMBL Approved Drugs
CHEMBL1200343
CHEMBL1581
CHEMBL3544986
ChEMBL Drugs
CHEMBL1200343
CHEMBL1581
CHEMBL3544986
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00790
DrugBank Approved Drugs
DB00790
DrugCentral
2108
DrugCentral Approved Drugs
2108
DrugMAP
DMOPZDT
DM8L6WB
DrugMAP Approved Drugs
DMOPZDT
Guide to Pharmacology
6367
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1581
MedChem Express Bioactive Compound Library
HY-B0130A
HY-B0130
NCATS Inxight Approved Drugs
TFT5IM1KGB
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T1484L
The Spectrum Collection
Tocris Bioactive Compound Library
4302
External IDs
84
Properties
(calculated by RDKit )
Molecular Weight
368.23
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
0
cLogP
1.94
TPSA
95.94
Fraction CSP3
0.84
Chiral centers
5.0
Largest ring
6.0
QED
0.64
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Endocrinology/Hormones
Immunology/Inflammation
Cell Cycle/DNA Damage
Epigenetics
JAK/STAT Signaling
Metabolic Enzyme/Protease
NF-κB
Stem Cell/Wnt
Target
MRP1
ACE
Angiotensin-converting Enzyme (ACE)
Sirtuin
STAT
Primary Target
Angiotensin-Converting Enzyme
MOA
MRP inhibitor
RAAS inhibitor
Inhibitor
angiotensin converting enzyme inhibitor
Indication
hypertension, myocardial infarction, coronary artery disease (CAD)
Therapeutic Class
Antihypertensive Agents
Solubility
Soluble in water, chloroform, methanol
Source data