General
Preferred name
tubocurarine
Synonyms
TUBOCURARINE CHLORIDE PENTAHYDRATE ()
Tubocurarine ()
Jexin ()
Tubarine ()
TUBOCURARINE CHLORIDE ()
(+)-Tubocurarine chloride ()
NSC-757362 ()
Curare ()
Tubocurarine chloride anhydrous ()
Tubaine ()
Tubarine pentahydrate ()
Tubocurarine chloride, anhydrous ()
Tubocurarini chloridum ()
Tubocurarine cation ()
d-Tubocurarine ()
Tubocurarine ion ()
P&D ID
PD009744
CAS
6989-98-6
57-94-3
57-95-4
1370-17-8
1390-11-0
8063-06-7
1406-69-5
41354-45-4
Tags
natural product
drug
available
Approved by
FDA
First approval
1945
Drug indication
Neuromuscular Blocking Agent
Anaesthesia
Smoking dependence
Drug Status
withdrawn
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tubocurarine is a skeletal muscle relaxant. The structure as specified by the FDA and the INN document shows the compound in complex with chloride (see PubChem CID 9917490). As our data specifies the parent compound, it is this structure we have chosen to display here, and which the majority of entries linked to from the table above display. (GtoPdb)
DESCRIPTION Selective KV11.1 (hERG) channel activator (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
20
ChEMBL Approved Drugs
CHEMBL3989821
CHEMBL339427
ChEMBL Drugs
CHEMBL3989821
CHEMBL339427
Concise Guide to Pharmacology 2017/18
2294
Concise Guide to Pharmacology 2019/20
2294
Concise Guide to Pharmacology 2021/22
2294
Concise Guide to Pharmacology 2023/24
2294
Drug Repurposing Hub
DrugBank
DB01199
DrugBank Approved Drugs
DB01199
DrugCentral
2781
DrugCentral Approved Drugs
2781
DrugMAP
DMBZIVP
DrugMAP Approved Drugs
DMBZIVP
Guide to Pharmacology
2294
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL339427
CHEMBL1687
NPC Screening Collection
ReFrame library
The Spectrum Collection
Tocris Bioactive Compound Library
2820
Withdrawn 2.0
25
External IDs
74
Properties
(calculated by RDKit )
Molecular Weight
609.3
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
8
Aromatic Ring Count
4
cLogP
6.7
TPSA
80.62
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
18.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Nicotinic Receptors (Non-selective)
MOA
Antagonist
acetylcholine receptor antagonist
Target
ACHE, CHRNA2, HTR3A, HTR3B, KCNN1, KCNN2, KCNN3, ZACN
Indication
anesthetic
ATC
M03AA02
Therapeutic Class
Neuromuscular Nondepolarizing Agents
Source data