General
Preferred name
ACAMPROSATE
Synonyms
ACAMPROSATE CALCIUM ()
Acamprosatum ()
Calcium N-acetylhomotaurinate ()
N-Acetylhomotaurine Calcium ()
calcium acetylhomotaurinate ()
Campral EC ()
Alcomed ()
Sobriol ()
acarbose ()
Acamprosate (calcium) ()
NSC-759186 ()
SN-102 ()
Campral ()
Acamprosato ()
Acamprosate (calcium salt) ()
Acamprosate-d3 (calcium salt) ()
P&D ID
PD009865
CAS
77337-76-9
56180-94-0
77337-73-6
1225580-94-8
Tags
available
drug
Approved by
FDA
First approval
2004
Drug indication
Alcohol dependence
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Acamprosate is a NMDA glutamate receptor antagonist and a positive allosteric modulator of GABAA receptors.
Marketed formulations contain acamprosate calcium (PubChem CID 155434). (GtoPdb)
DESCRIPTION GluK1 antagonist; inhibits carbonic anhydrase (CA) II and IV; also positive allosteric modulator of GABAA receptors (Tocris Bioactive Compound Library)
Compound Sets
26
Cayman Chemical Bioactives
23899
26780
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL2068724
CHEMBL1201293
ChEMBL Drugs
CHEMBL2068724
CHEMBL1201293
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00659
DrugBank Approved Drugs
DB00659
DrugCentral
38
DrugCentral Approved Drugs
38
DrugMAP
DMO381I
DrugMAP Approved Drugs
DMO381I
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
7106
Ki Database
Acamprosate
MedChem Express Bioactive Compound Library
HY-17030
NCATS Inxight Approved Drugs
N4K14YGM3J
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
TargetMol Bioactive Compound Library
T1673
The Spectrum Collection
Tocris Bioactive Compound Library
3618
External IDs
67
Properties
(calculated by RDKit )
Molecular Weight
181.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
-0.6
TPSA
83.47
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ionotropic glutamate receptor antagonist
Agonist
mgluR)
NMDA Antagonists
Drugs Acting on Glutamate Receptors (Metabotropic
"mgluR)
Drugs Acting on Glutamate Receptors (Metabotropic"
glutamate receptor antagonist
Target
GABA-A receptor
anion channel
Glutamate [NMDA] receptor
GABAR
GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM5
GABA Receptor
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
Primary Target
Miscellaneous GABA
Member status
member
Indication
abstinence from alcohol
Therapeutic Class
Alcohol Deterrents
Source data