General
Preferred name
NICARDIPINE
Synonyms
NICARDIPINE HYDROCHLORIDE ()
YC-93 (free base) ()
YC-93 ()
YC-93 Hydrochloride ()
Nicardipine HCl ()
RS-69216 ()
Nicardipine (Hydrochloride) ()
RS-69216,YC-93 ()
Perdipina ()
RS-69216XX07-0 ()
Nicarpin ()
Rycarden ()
Lecibral ()
Ridene ()
Vasonase ()
Cardepine ()
Dacarel ()
Rydene ()
Nicodel ()
Lescodil ()
Ranvil ()
Nimicor ()
Nicardal ()
RS-69216-XX-07-0 ()
NSC-757855 ()
Loxen ()
Cardene ()
Vasodin ()
Nerdipina ()
Lecibra ()
Nicapress ()
Barizin ()
Cardene Sr ()
Nicant ()
Perdipine ()
Nicardipine (stn) ()
Nicardipino ()
Perpidine ()
P&D ID
PD009884
CAS
54527-84-3
55985-32-5
69441-18-5
106664-28-2
Tags
available
drug
Approved by
FDA
First approval
1988
Drug indication
High blood pressure
Vasodilator
Drug Status
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION One of the dihydropyridine class of drugs. (GtoPdb)
DESCRIPTION L-type Ca2+ channel antagonist; antihypertensive (LOPAC library)
Cell lines
1
Organisms
9
Compound Sets
26
Axon Medchem Screening Library
3254
Cayman Chemical Bioactives
17537
ChEMBL Approved Drugs
CHEMBL1200326
CHEMBL1484
ChEMBL Drugs
CHEMBL1200326
CHEMBL1484
CZ-OPENSCREEN Bioactive Library
DrugBank
DB00622
DrugBank Approved Drugs
DB00622
DrugCentral
1909
DrugCentral Approved Drugs
1909
DrugMAP
DMCDYW7
DrugMAP Approved Drugs
DMCDYW7
DrugMatrix
Enamine BioReference Compounds
Guide to Pharmacology
2559
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200326
CHEMBL1484
Mcule NIBR MoA Box Subset
MCULE-8941631263
MedChem Express Bioactive Compound Library
HY-12515A
HY-12515
NCATS Inxight Approved Drugs
CZ5312222S
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
nicardipine-hcl
nicardipine
TargetMol Bioactive Compound Library
T1215
The Spectrum Collection
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
479.21
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
3
Aromatic Ring Count
2
cLogP
3.68
TPSA
111.01
Fraction CSP3
0.31
Chiral centers
1.0
Largest ring
6.0
QED
0.33
Structural alerts
2
aggregator (ZINC)
Aggregators
aggregator (Aggregator Advisor)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
L-type
Pathway
Neuroscience
Membrane Transporter/Ion Channel
GPCR/G protein
Neuronal Signaling
Autophagy
Target
mAChR
Adrenergic Receptor
Calcium Channel
Ca channel antagonist
ADC Cytotoxin,Calcium Channel
Member status
member
MOA
Calcium Channel Blockers
Therapeutic Class
Antihypertensive Agents
Source data