General
Preferred name
AMODIAQUINE
Synonyms
AMODIAQUINE HYDROCHLORIDE ()
Amodiaquin dihydrochloride dihydrate ()
Amodiaquine dihydrochloride dihydrate ()
Amodiaquine dihydrochloride dihydrate ()
Amodiaquin (dihydrochloride dihydrate) ()
Amodiaquin ()
Amodiaquin (dihydrochloride) ()
Amodiaquine (dihydrochloride dihydrate) ()
Amodiaquine (dihydrochloride) ()
Amodiaquine-d10 ()
Camoquin hydrochloride ()
Amodiaquini hydrochloridum ()
Amodiaquine HCl ()
NSC-755863 ()
GNF-Pf-5648 ()
Amodiaquinum ()
NSC-13453 ()
SJ000110703 ()
Sunoquine ()
TCMDC-123932 ()
Camoquin HCl ()
P&D ID
PD009890
CAS
6398-98-7
86-42-0
69-44-3
1021496-19-4
1189449-70-4
Tags
natural product
drug
available
Approved by
FDA
Drug indication
Antimalarial
Antimalarial,Antiprotozoal
Malaria
Drug Status
investigational
withdrawn
approved
Max Phase
4.0
First approval
1982
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amodiaquine is the non-proprietary name of the active antimalarial that is contained in a number of drugs that are approved in jurisdictions in Africa (Kenya and Tanzania), Colombia and Pakistan. It is a 4-aminoquinoline compound related to .

Potential Target/Mechanism Of Action: As the precise mechanism of action of amodiaquine is not yet known, we do not have a molecular target for this compound.
DESCRIPTION Amodiaquine is a 4-aminoquinoline antimalarial compound related to .

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION Amodiaquine is a drug which used to treat malaria, including Plasmodium falciparum malaria when uncomplicated. It has similar action to chloroquine. It is not available in the United States, but widely available in Africa. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
9
Compound Sets
28
AdooQ Bioactive Compound Library
A16405
BOC Sciences Bioactive Compounds
amodiaquine-cas-86-42-0-item-78564
Cayman Chemical Bioactives
15954
28525
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1357648
CHEMBL682
ChEMBL Drugs
CHEMBL1357648
CHEMBL682
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00613
DrugBank Approved Drugs
DB00613
DrugCentral
186
DrugCentral Approved Drugs
186
DrugMAP
DME4RA8
DrugMAP Approved Drugs
DME4RA8
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100364
Guide to Pharmacology
10018
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1630
MedChem Express Bioactive Compound Library
HY-B1322
HY-B1322A
HY-B1322B
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
amodiaquine-dihydrochloride-dihydrate
amodiaquine
amodiaquine-hydrochloride
TargetMol Bioactive Compound Library
T0381
Withdrawn 2.0
61
ZINC Tool Compounds
ZINC000000608172
External IDs
84
Properties
(calculated by RDKit )
Molecular Weight
355.15
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
5.18
TPSA
48.39
Fraction CSP3
0.25
Chiral centers
0.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Histamine N-methyltransferase inhibitor
Histamine Methyltransferase Inhibitor
Antimalarial
Histamine Receptor agonist
Target
Ferriprotoporphyrin IX
histamine N-methyl transferase
HNMT
Histone methyltransferase
Nuclear Hormone Receptor 4A/NR4A
Parasite
Histone Methyltransferase,HNMT,Transferase
Immunology & Inflammation related
DNA/RNA Synthesis,Parasite
Pathway
GPCR/G protein
Immunology/Inflammation
Neuroscience
Anti-infection
Epigenetics
Vitamin D Related/Nuclear Receptor
Member status
member
Indication
malaria
ATC
P01BA06
Therapeutic Class
Antimalarials
Solubility
DMSO (Slightly), Methanol (Slightly)
Source data