General
Preferred name
LABETALOL
Synonyms
DILEVALOL ()
LABETALOL HYDROCHLORIDE ()
AH5158 ()
Sch-15719W (free base) ()
Sch-15719W ()
AH-5158 hydrochloride ()
Labetalol HCl ()
Labetalol (hydrochloride) ()
AH-5158 hydrochloride,Labetalol hydrochloride,Sch-15719W ()
Labetalol hydrochloride in sodium chloride ()
Ibidomide hydrochloride ()
SCH-15719W HYDROCHLORIDE ()
AH 5158A ()
AH-5158A ()
Normodyne ()
SCH 15719W ()
Trandate ()
Labetalol Hydrocloride ()
AH-5158A HYDROCHLORIDE ()
Labetalol hydrochloride in dextrose ()
Labrocol ()
NSC-290312 ()
SCH-15719W FREE BASE ()
Normozide ()
Ibidomide ()
AH-5158A FREE BASE ()
Labetalol-d5 (hydrochloride) ()
P&D ID
PD009899
CAS
32780-64-6
36894-69-6
32780-40-8
2713514-78-2
Tags
available
drug
Approved by
FDA
First approval
1984
Drug indication
Anti-Adrenergic (beta-receptor)
Anti-Adrenergic (alpha-receptor)
Hypertension
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Marketed formulations may contain labetalol hydrochloride (PubChem CID 71412). (GtoPdb)
DESCRIPTION Competitive beta-adrenoceptor antagonist (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
28
AdooQ Bioactive Compound Library
A14239
Cayman Chemical Bioactives
20249
26289
31609
ChEMBL Approved Drugs
CHEMBL1200323
CHEMBL429
ChEMBL Drugs
CHEMBL1200323
CHEMBL429
Concise Guide to Pharmacology 2017/18
7207
Concise Guide to Pharmacology 2019/20
7207
Concise Guide to Pharmacology 2021/22
7207
Concise Guide to Pharmacology 2023/24
7207
DrugBank
DB00598
DrugBank Approved Drugs
DB00598
DrugCentral
1531
DrugCentral Approved Drugs
1531
DrugMAP
DMK8U72
DrugMAP Approved Drugs
DMK8U72
DrugMatrix
Guide to Pharmacology
7207
Ki Database
LABETALOL
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1200323
CHEMBL429
MedChem Express Bioactive Compound Library
HY-B1108
HY-121383
NCATS Inxight Approved Drugs
R5H8897N95
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
labetalol-hcl
TargetMol Bioactive Compound Library
T0348
The Spectrum Collection
External IDs
60
Properties
(calculated by RDKit )
Molecular Weight
328.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
4
Rotatable Bonds
8
Ring Count
2
Aromatic Ring Count
2
cLogP
2.14
TPSA
95.58
Fraction CSP3
0.32
Chiral centers
2.0
Largest ring
6.0
QED
0.6
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
beta
Pathway
GPCR/G protein
Neuronal Signaling
Target
??1-adrenergic receptor
Adrenergic Receptor
Member status
member
MOA
alpha-Adrenoceptor Antagonists
beta-Adrenoceptor Antagonists
Therapeutic Class
Antihypertensive Agents
Source data