General
Preferred name
AMILORIDE
Synonyms
AMILORIDE HYDROCHLORIDE ()
Midamor ()
MK-870 hydrochloride ()
Amiloride HCl ()
Amiloride hydrochloride dihydrate ()
Amiloride HCl 2H2O ()
Amiloride HCl 2H2O ()
MK-870 ()
MK-870 hydrochloride dihydrate ()
Amiloride (hydrochloride) ()
Amiloride (MK-870) HCl ()
Amiloride HCl dihydrate ()
MK-870 HCl ()
NSC-755847 ()
Anhydrous amiloride hydrochloride ()
Amilospare 5 ()
Berkamil ()
Amiloridi hydrochloridum ()
Amiloride hydrochloride anhydrous ()
Amoride ()
Amiloride hydrochloride dehydrate ()
Amilamont ()
Amipramidine ()
Hydro-Ride ()
Amilorida ()
Amiclaran ()
Amiloride (hydrochloride) (hydrate) ()
P&D ID
PD009902
CAS
17440-83-4
2609-46-3
2016-88-8
Tags
available
drug
Approved by
FDA
First approval
1981
Drug indication
Diuretic
Congestive heart failure
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amiloride is a loop diuretic drug. (GtoPdb)
DESCRIPTION NMDA antagonist; acts at glycine site (Tocris Bioactive Compound Library)
DESCRIPTION Epithelial Na+ channel blocker (LOPAC library)
DESCRIPTION Amiloride HCl is a relatively selective inhibitor of the epithelial sodium channel, used in the management of hypertension and congestive heart failure. (BOC Sciences Bioactive Compounds)
DESCRIPTION Na+ channel blocker. Also I2 imidazoline ligand (Tocriscreen Total)
Cell lines
1
Organisms
2
Compound Sets
37
AdooQ Bioactive Compound Library
A10064
A11728
BOC Sciences Bioactive Compounds
amiloride-hcl-cas-2016-88-8-333112
Cayman Chemical Bioactives
14409
26295
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1398126
CHEMBL945
ChEMBL Drugs
CHEMBL1398126
CHEMBL945
Concise Guide to Pharmacology 2017/18
2421
Concise Guide to Pharmacology 2019/20
2421
Concise Guide to Pharmacology 2021/22
2421
Concise Guide to Pharmacology 2023/24
2421
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00594
DrugBank Approved Drugs
DB00594
DrugCentral
158
DrugCentral Approved Drugs
158
DrugMAP
DMRTSGP
DrugMAP Approved Drugs
DMRTSGP
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100915
Guide to Pharmacology
2421
JUMP-Target 1 Compound Set
16231
Ki Database
Amiloride
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1398126
CHEMBL945
MedChem Express Bioactive Compound Library
HY-B0285A
HY-B0285B
HY-B0285
NCATS Inxight Approved Drugs
7DZO8EB0Z3
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Amiloride-hydrochloride(Midamor)
amilorida
TargetMol Bioactive Compound Library
T0175
The Spectrum Collection
Tocris Bioactive Compound Library
0890
Tocriscreen Total
External IDs
93
Properties
(calculated by RDKit )
Molecular Weight
229.05
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
5
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-1.08
TPSA
156.79
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Epithelial
MOA
amiloride-sensitive sodium channel inhibitor
Serine Protease inhibitor
Blocker
Sodium Channel blocker
Target
Amiloride-sensitive sodium channel, ENaC
uPA
AOC1, ASIC1, ASIC2, ASIC3, PKD2, PKD2L1, PLAU, SCNN1A, SCNN1B, SCNN1D, SCNN1G, SLC9A1, TRPC7, TRPV2
ASIC1
Sodium Channel
TRP Channel
Calcium Channel,Serine Protease,Sodium Channel
Pathway
Proteases/Proteasome
Apoptosis
Membrane Transporter/Ion Channel
Neuronal Signaling
Primary Target
Voltage-gated Sodium (NaV) Channels
Indication
hypertension, congestive heart failure
Therapeutic Class
Diuretics
Solubility
Well in water and ethanol
Source data