General
Preferred name
DICLOFENAC
Synonyms
DICLOFENAC SODIUM ()
Diclofenac hydroxyethylpyrrolidine ()
GP 45840 ()
Diclofenacum ()
Voltaren ()
Diclofenac sodium salt ()
Diclofenac Diethylamine ()
"Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, monosodium salt" ()
DICLOFENAC EPOLAMINE ()
Diclofenac (diethylamine) ()
Diclofenac (Sodium) ()
Diclofenac (potassium) ()
DICLOFENAC POTASSIUM ()
Diclofenac acid ()
CGP-45840B ()
DHEP, DIEP, diclofenac hydroxyethylpyrrolidine ()
{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid ()
Diclofenac (sodium salt) ()
Diclofenac-d4 ()
Primofenac ()
Dicloflex ()
Dicloflex SR ()
Rheumatac Ret 75 ()
Benfofen ()
Econac ()
Defanac Retard ()
Fenactol ()
Prophenatin ()
Voltarol Emulgel P ()
Diclomax SR ()
Arthrotec 75 ()
Pennsaid ()
Mobigel Paineze ()
Motifene ()
Isclofen ()
Fenactol Ret ()
Voltarol ()
Lexobene ()
Flamrase ()
Rhumalgan ()
Dyloject ()
Diclomax ()
Diclomax Ret ()
Flamatak MR ()
Volsaid Ret 75 ()
Delphinac ()
Dexomon Ret ()
Dealgic ()
Voldal ()
Flamrase SR ()
Rhumalgan SR ()
NSC-756725 ()
Neriodin ()
Diclovol Ret ()
Lofensaid 50 ()
Lofensaid Ret 100 ()
Voltarene ()
Acoflam Ret ()
Voltaren arthritis pain ()
Digenac XL 100 ()
Defanac ()
Voltaren Ret ()
Arthronac ()
Xenid ()
Econac SR ()
Lofensaid Ret 75 ()
Diclovol SR ()
Voltaren Emulgel ()
Valdic 100 Ret ()
Diclophenac sodium ()
Dexomon SR ()
Voltarol Active ()
Voltarol Gel Patch ()
Voltarol Ophtha ()
Arthrotec 50 ()
Voltarene Emulgel ()
Voltaren-XR ()
Enzed ()
Novapirina ()
Solaraze ()
Difenor XL ()
Dicloflex Ret ()
Diclofenac diethylammonium salt ()
Enstar XL ()
Effekton ()
Diclofenac diethylamine salt ()
Defanac SR ()
Duravolten ()
Fenactol SR ()
Diclofenac diethylammonium ()
Deflamat ()
Econac XL ()
Voltarol Emulgel ()
Diclozip 50 ()
Acoflam ()
Rhumalgan CR 75 ()
Voltarene L.P. ()
Rhumalgan XL ()
Acoflam SR ()
Diclofenac sod ()
Rewodina ()
Valdic 75 Ret ()
Misofen ()
Rhumalgan CR 100 ()
Lofensaid 25 ()
Valenac ()
Diclophlogont ()
Dicloreum ()
Closteril 100 ()
Volraman ()
Volsaid Ret 100 ()
Voltarol Ret ()
Voltarol SR ()
Diclotard 75 MR ()
Flexotard MR ()
Abitren ()
Enstar SR ()
Voltarol 12 Hour Emulgel P ()
Ecofenac ()
Diclozip 25 ()
Diclotard 100 MR ()
Sodium diclofenac ()
Mobigel ()
Diclovol ()
Slofenac ()
Voltarol Pain-eze Emulgel ()
Voltarene Ret ()
GP-45840 ()
Masidemen ()
LAS41007 ()
Diclofenac free acid ()
Cataflam ()
Voltaren Ophthalmic ()
Zorvolex ()
Zorvolex Capsules ()
Arthrotec ()
Cambia ()
LAS-41007 ()
Voltaren Xr ()
Voltarol Rapid ()
Potassium diclofenac ()
Voltarol Pain-eze ()
CGP 45840B ()
Zipsor ()
Voltarol Joint Pain ()
Diclofenac potassium salt ()
Voltarol Pain-eze Extra Strgh ()
Flector ()
Flector Patch ()
Licart ()
Diclofenac epolaminum ()
DICLOFENAC FREE ACID ()
Voltaren XR ()
ZORVOLEX ()
P&D ID
PD009905
CAS
15307-79-6
78213-16-8
15307-86-5
153466-65-0
15307-81-0
119623-66-4
128402-48-2
Tags
available
natural product
drug
Approved by
PMDA
FDA
First approval
2007
1988
1993
Drug indication
Osteoarthritis
Anti-Inflammatory
Drug Status
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) (GtoPdb)
DESCRIPTION Potent and selective PLK2 inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Cyclooxygenase inhibitor; anti-inflammatory (LOPAC library)
Cell lines
3
Organisms
2
Compound Sets
37
AdooQ Bioactive Compound Library
A10304
Cayman Chemical Bioactives
70680
19072
22983
ChEMBL Approved Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
ChEMBL Drugs
CHEMBL1034
CHEMBL139
CHEMBL1200804
CHEMBL1201180
Concise Guide to Pharmacology 2017/18
2714
Concise Guide to Pharmacology 2019/20
2714
Concise Guide to Pharmacology 2021/22
2714
Concise Guide to Pharmacology 2023/24
2714
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00586
DrugBank Approved Drugs
DB00586
DrugCentral
865
DrugCentral Approved Drugs
865
DrugMAP
DMPIHLS
DrugMAP Approved Drugs
DMPIHLS
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100332
EUbOPEN Chemogenomics Library
Guide to Pharmacology
2714
IPPI - DB
1993
Ki Database
Diclofenac sodium salt
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1034
CHEMBL139
MedChem Express Bioactive Compound Library
HY-15037
HY-15036
HY-15036A
HY-15038
HY-109547
NCATS Inxight Approved Drugs
144O8QL0L1
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Diclofenac-sodium
diclofenac-acid
diclofenac-diethylamine
diclofenac-potassium
diclofenac-epolamine
TargetMol Bioactive Compound Library
T1555
T0196
T0432
The Spectrum Collection
Tocris Bioactive Compound Library
4454
External IDs
150
Properties
(calculated by RDKit )
Molecular Weight
295.02
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.36
TPSA
49.33
Fraction CSP3
0.07
Chiral centers
0.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
COX
Pathway
Immunology/Inflammation
Neuroscience
Apoptosis
Target
COX-1
COX-2
huMan COX-2(in CHO cells)
human COX-1(in CHO cells)
ovine COX-2
ovine COX-1
AKR1C3, ALOX5, ASIC1, ASIC3, KCNQ2, KCNQ3, PLA2G2A, PPARG, PTGS1, PTGS2, SCN4A
Immunology & Inflammation related
COX,Immunology & Inflammation related
Primary Target
Cyclooxygenases
MOA
COX inhibitor
Inhibitor
Cyclooxygenase-3 Inhibitors
Cyclooxygenase-1 Inhibitors
Cyclooxygenase-2 Inhibitors
Non-Steroidal Antiinflammatory Drugs
Voltage-Gated K(V) 7.2 (KCNQ2) Channel Activators
cyclooxygenase inhibitor
Member status
virtual
Indication
rheumatoid arthritis, osteoarthritis, migraine headache
Disease Area
rheumatology, neurology/psychiatry
Therapeutic Class
Neurology Agents
Recommended Cell Concentration
None
Source data