General
Preferred name
CLONIDINE
Synonyms
CLONIDINE HYDROCHLORIDE ()
Clonidine HCl ()
Catapres ()
Clonidine (hydrochloride) ()
Ipotensium ()
Kapvay ()
NSC-756699 ()
CATAPRES TTS 3 ()
DICHLORANILINO IMIDAZOLIN ()
CATAPRES P.L. ()
DIXARIT ()
CATAPRES TTS 2 ()
DURACLON ()
CATAPRES TTS 1 ()
JENLOGA ()
ST-155 ()
Clonidine extended release ()
Catapres-Tts-2 ()
Catapres-Tts-1 ()
ST-155BS ()
Combipres ()
Clonidina ()
Nexiclon xr ()
ST-155-BS ()
Clorpres ()
Catapres-Tts-3 ()
Catarpres-tts ()
Clonidine (hydrochloride) ()
Clonidine-d4 (hydrochloride) ()
P&D ID
PD009910
CAS
4205-91-8
4205-90-7
67151-02-4
Tags
available
biased GPCR ligand
drug
Approved by
FDA
First approval
1974
Drug indication
Antihypertensive
Diabetic neuropathy
Hypertension
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Clonidine is an α2 adrenoceptor agonist.
The structure shown here is in the amino form. A tautomeric imino form, represented by CHEBI:3757 also exists. (GtoPdb)
DESCRIPTION Muscarinic agonist (Tocris Bioactive Compound Library)
DESCRIPTION alpha2 Adrenoceptor agonist; antihypertensive (LOPAC library)
DESCRIPTION α2 agonist. Also I1 ligand (Tocriscreen Total)
Compound Sets
38
AdooQ Bioactive Compound Library
A10232
Axon Medchem Screening Library
3044
BiasDB
Clonidine
Cayman Chemical Bioactives
15949
38558
28519
ChEMBL Approved Drugs
CHEMBL1705
CHEMBL134
ChEMBL Drugs
CHEMBL1705
CHEMBL134
Concise Guide to Pharmacology 2017/18
516
Concise Guide to Pharmacology 2019/20
516
Concise Guide to Pharmacology 2021/22
516
Concise Guide to Pharmacology 2023/24
516
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00575
DrugBank Approved Drugs
DB00575
DrugCentral
704
DrugCentral Approved Drugs
704
DrugMAP
DM6RZ9Q
DrugMAP Approved Drugs
DM6RZ9Q
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101811
EUbOPEN Chemogenomics Library
EUB0000904
Guide to Pharmacology
13162
516
Ki Database
CLONIDINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1705
CHEMBL134
MedChem Express Bioactive Compound Library
HY-B0409A
HY-12721
NCATS Inxight Approved Drugs
MN3L5RMN02
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Clonidine-hydrochloride(Catapres)
TargetMol Bioactive Compound Library
T1247
The Spectrum Collection
Tocris Bioactive Compound Library
0690
Tocriscreen Total
External IDs
78
Properties
(calculated by RDKit )
Molecular Weight
229.02
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
1
Ring Count
2
Aromatic Ring Count
1
cLogP
2.36
TPSA
36.42
Fraction CSP3
0.22
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
2
aggregator (ZINC)
Aggregators
aggregator (Aggregator Advisor)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
Selectivity
alpha2
Pathway
GPCR/G protein
Neuronal Signaling
Target
??2 adrenergic receptor
ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C
a2 agonist
Adrenergic Receptor
Adrenergic Receptor,Autophagy
Primary Target
Adrenergic ?2 Receptors
MOA
Agonist
alpha2-Adrenoceptor Agonists
ADRA1B gene stimulator
Adrenergic Receptor agonist
Member status
virtual
Disease Area
cardiology, neurology/psychiatry
Indication
hypertension, attention-deficit/hyperactivity disorder (ADHD)
Therapeutic Class
Antihypertensive Agents
Recommended Cell Concentration
None
Source data