General
Preferred name
dextromethorphan
Synonyms
DEXTROMETHORPHAN HYDROBROMIDE ()
Dextromethorphan hydrobromide hydrate ()
DEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE ()
Dextromethorphan HBr monohydrate ()
Dextromethorphan polistirex ()
AVP-786 ()
Dextromethorphan+quinidine ()
Dextromethorphan HBr ()
Delsym ()
Deudextromethorphan (AVP-786) ()
Dextromethorphan Hydrobromide ()
Dextromethorphan Hydrobromide Monohydrate ()
Contac Coughcaps ()
Franolyn Dry ()
Tussabron ()
Tuxium ()
Franolyn Sed ()
Beecham Coughcaps ()
Brontyl ()
NSC-756723 ()
Dextrometorfano ()
Dimetane-DX ()
Dextromethorphane ()
NSC-751452 ()
d6-DM ()
C100003 ()
Dextromethorphan d6 ()
Deudextrometorfano ()
C-10003 ()
C10003 ()
Deudextromethorphane ()
D6-dextromethorphan ()
CTP-786 ()
DEUDEXTROMETHORPHAN ()
D6-dm hydrobromide monohydrate ()
d6-DM hydrobromide ()
DEUDEXTROMETHORPHAN HYDROBROMIDE ()
Dextromethorphan (hydrobromide hydrate) ()
P&D ID
PD009985
CAS
6700-34-1
125-71-3
125-69-9
1079043-55-2
Tags
available
drug
drug candidate
Approved by
FDA
First approval
1982
1984
1957
Drug indication
Antitussive
Dry cough
Pain
Diabetic neuropathy
Alzheimer disease
Cough
Neurobehavioral disorder
Schizophrenia
Drug Status
approved
investigational
Max Phase
4.0
2.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Dextromethorphan is a morphinan class sedative. It is available over-the-counter (OTC) for use as an antitussive. At doses much higher than medically recommended, dextromethorphan is used recreationally for its dissociative anesthetic and euphoria producing effects. (GtoPdb)
Cell lines
0
Organisms
1
Compound Sets
23
Cayman Chemical Bioactives
13950
11157
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1256818
CHEMBL52440
ChEMBL Drugs
CHEMBL1256818
CHEMBL52440
CHEMBL3989940
CHEMBL3989946
Concise Guide to Pharmacology 2023/24
6953
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00514
DrugBank Approved Drugs
DB00514
DrugCentral
842
DrugCentral Approved Drugs
842
DrugMAP
DMEHCY5
DMFI5J4
DMUDJZM
DMV1SOR
DrugMAP Approved Drugs
DMEHCY5
DMUDJZM
Guide to Pharmacology
6953
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL52440
NCATS Inxight Approved Drugs
7355X3ROTS
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
deudextromethorphan-avp-786
TargetMol Bioactive Compound Library
T0262
The Spectrum Collection
External IDs
83
Properties
(calculated by RDKit )
Molecular Weight
271.19
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
1
cLogP
3.38
TPSA
12.47
Fraction CSP3
0.67
Chiral centers
3.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
ionotropic glutamate receptor antagonist
sigma-1 receptor agonist
NMDA Antagonists
sigma1 Receptor Agonists
glutamate receptor antagonist, sigma receptor agonist
Target
alpha4/beta2
Sigma opioid receptor
Glutamate receptor ionotropic, NMDA 3A
Neuronal acetylcholine receptor
alpha2/beta2
Glutamate [NMDA] receptor subunit epsilon 1
alpha3/beta2
Sodium-dependent serotonin transporter
nAChR
??-opioid receptor
CHRNA2, CHRNA3, CHRNA4, CHRNA7, CHRNB2, CHRNB4, CYBA, CYBB, GRIN3A, NCF1, NCF2, NCF4, OPRD1, OPRK1, OPRM1, PGRMC1, RAC1, RAC2, SIGMAR1, SLC6A2, SLC6A4
NMDAR
Pathway
Endocrinology/Hormones
Neuroscience
GPCR/G protein
Member status
virtual
Indication
cough suppressant
Therapeutic Class
Analgesics
Source data