General
Preferred name
TRIFLUPROMAZINE
Synonyms
TRIFLUPROMAZINE HYDROCHLORIDE ()
Trifluopromazine ()
Fluopromazine hydrochloride ()
Flumazin ()
Fluorofen ()
Neoprin ()
MC-4703 ()
Triflupromazine hcl ()
NSC-17473 ()
Vesprin ()
NSC-14959 ()
Fluopromazine ()
Nivoman ()
Vetame ()
Triflupromazina ()
Triflupromazine (hydrochloride) ()
P&D ID
PD009989
CAS
1098-60-8
146-54-3
Tags
available
drug
Approved by
FDA
First approval
1957
Drug indication
Middle East Respiratory Syndrome (MERS)
Psychotic disorder
Antipsychotic
Severe acute respiratory syndrome (SARS)
Psychosis
Drug Status
approved
withdrawn
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Triflupromazine is a phenothiazine class antipsychotic drug. (GtoPdb)
DESCRIPTION The hydrochloride salt form of Triflupromazine, an analogue of Chlorpromazine, is effective as nntipsychotic drug and antemetic agent. (BOC Sciences Bioactive Compounds)
DESCRIPTION D2 dopamine receptor antagonist; phenothiazine antipsychotic (LOPAC library)
DESCRIPTION Triflupromazine, a phenothiazin derivative, has been found to be a D2 dopamine receptor antagonist that could probably used as a tranquilizer and antipsychotic agent. (BOC Sciences Bioactive Compounds)
Cell lines
1
Organisms
4
Compound Sets
30
BOC Sciences Bioactive Compounds
triflupromazine-hydrochloride-cas-1098-60-8-item-195568
triflupromazine-cas-146-54-3-item-59061
Cayman Chemical Bioactives
27610
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL1201102
CHEMBL570
ChEMBL Drugs
CHEMBL1201102
CHEMBL570
Concise Guide to Pharmacology 2017/18
4330
Concise Guide to Pharmacology 2019/20
4330
Concise Guide to Pharmacology 2021/22
4330
Concise Guide to Pharmacology 2023/24
4330
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00508
DrugBank Approved Drugs
DB00508
DrugCentral
2742
DrugCentral Approved Drugs
2742
DrugMAP
DMIZX8P
DMKFQJP
DrugMAP Approved Drugs
DMKFQJP
Enamine BioReference Compounds
Guide to Pharmacology
4330
Ki Database
Trifluopromazine
Triflupromazine
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201102
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
triflupromazine-hydrochloride
TargetMol Bioactive Compound Library
T0302
The Spectrum Collection
Withdrawn 2.0
220
ZINC Tool Compounds
ZINC000000538507
External IDs
47
Properties
(calculated by RDKit )
Molecular Weight
352.12
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
5.26
TPSA
6.48
Fraction CSP3
0.33
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D2
MOA
Dopamine Receptor antagonist
Histamine Receptor antagonist
serotonin receptor antagonist
muscarinic acetylcholine receptor antagonist
alpha adrenergic receptor antagonist
Target
Dopamine D2 receptor
5-HT
mAChR
dopamine
CHRM1, CHRM2, DRD1, DRD2, HTR2B
Dopamine Receptor
Pathway
GPCR/G protein
Neuroscience
Indication
psychosis, nausea, vomiting
Disease Area
neurology/psychiatry, gastroenterology
ATC
N05AA05
Therapeutic Class
Antipsychotic Agents
Antiviral Agents
Solubility
DMSO:27mg/mL
Source data