General
Preferred name
FLUOXETINE
Synonyms
FLUOXETINE HYDROCHLORIDE ()
LY-110140 (free base) ()
LY-110140 ()
Fluoxetine HCl ()
Lilly110140 ()
Fluoxetine (HCl) ()
Fluoxetine (Lilly 110140) HCl ()
Prozac, Sarafem,LY-110140 ()
RECONCILE ()
FLUCTIN ()
FONTEX ()
RANFLUTIN ()
PROZAC WEEKLY ()
FLUOXEREN ()
SARAFEM ()
PROZAC ()
SELFEMRA ()
FLUOXETINE (AS HYDROCHLORIDE) ()
Fluoxetine ()
PROZAC 60 ()
OLENA ()
FLUNEURIN ()
ADOFEN ()
LY110140 ()
PROZEP ()
FLUOX-PUREN ()
FELICIUM ()
LOVAN ()
FLUSOL ()
PROZIT ()
FOXETIN ()
OXACTIN ()
FLUXET ()
Fluoxetin ratiopharm ()
Symbyax ()
Fluval ()
Fluoxetina ()
NSC-758685 ()
NSC-283480 ()
Fluoxetine (hydrochloride) ()
Fluoxetine-d5 (hydrochloride) ()
Fluoxetine (hydrochloride) (CRM) ()
P&D ID
PD010007
CAS
56296-78-7
52341-67-0
59333-67-4
100568-02-3
54910-89-3
1173020-43-3
Tags
available
nuisance
drug
Approved by
FDA
First approval
1987
Drug indication
Depression
Antidepressant
Drug Status
approved
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
HALF-LIFE 1-3 days [acute administration];; 4-6 days [chronic administration];; 4-16 days [norfluoxetine, acute and chronic administration].
DESCRIPTION The approved drug fluoxetine is a racemic mixture of two enantiomers; (R)-fluoxetine and (S)-Fluoxetine. The structure shown here does not specify stereochemistry and represents the mixture. The two PDB links listed above represent the two enantiomers. Fluoxetine is metabolised in the body to active metabolite . (GtoPdb)
DESCRIPTION sigma1 selective antagonist (Tocris Bioactive Compound Library)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Plus)
DESCRIPTION Selective serotonin reuptake inhibitor (LOPAC library)
DESCRIPTION 5-HT re-uptake inhibitor (Tocriscreen Total)
Cell lines
4
Organisms
8
Compound Sets
38
Axon Medchem Screening Library
1302
Cayman Chemical Bioactives
14418
32720
18253
ChEMBL Approved Drugs
CHEMBL1201082
CHEMBL41
ChEMBL Drugs
CHEMBL1201082
CHEMBL41
Concise Guide to Pharmacology 2017/18
203
Concise Guide to Pharmacology 2019/20
203
Concise Guide to Pharmacology 2021/22
203
Concise Guide to Pharmacology 2023/24
203
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00472
DrugBank Approved Drugs
DB00472
DrugCentral
1209
DrugCentral Approved Drugs
1209
DrugMAP
DM3PD2C
DrugMAP Approved Drugs
DM3PD2C
DrugMatrix
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101181
EUbOPEN Chemogenomics Library
EUB0000428
Guide to Pharmacology
203
Ki Database
FLUOXETINE
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL1201082
CHEMBL41
NCATS Inxight Approved Drugs
01K63SUP8D
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Fluoxetine-hydrochloride
TargetMol Bioactive Compound Library
T0450L
The Pathogen Box
The Spectrum Collection
Tocris Bioactive Compound Library
0927
Tocriscreen Plus
0927
Tocriscreen Total
External IDs
82
Properties
(calculated by RDKit )
Molecular Weight
309.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
4.44
TPSA
21.26
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.85
Structural alerts
1
CAD
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Transporters
Selectivity
Reuptake
Target
Serotonin Transporter
Autophagy
5-HT
Sert (Sodium-dependent)
ANO1, HTR2B, SLC6A4
SSRI
5-HT Receptor
Disease
KINETOPLASTIDS
Pathway
Neuronal Signaling
GPCR/G protein
Neuroscience
Primary Target
5-HT Transporters
MOA
Inhibitor
Sodium Channel Blockers
Serotonin Transporter (SERT) Inhibitors
selective serotonin reuptake inhibitor (SSRI)
Member status
member
Indication
depression, obsessive compulsive disorder (OCD), bulimia nervosa, panic disorders, bipolar disorder
Therapeutic Class
Antidepressants
Recommended Cell Concentration
None
Source data