General
Preferred name
quinine
Synonyms
Quinine bimuriate ()
QUININE DIHYDROCHLORIDE ()
Quinine (hydrochloride dihydrate) ()
Quinine HCl Dihydrate ()
Rezquin ()
NSC-192949 ()
(8s,9r)-6'-methoxycinchonan-9-ol ()
WR297608 ()
Chininum purum ()
Gls-1200 ()
Quinamm ()
Quinine hemisulfate anhydrous ()
Quinine sulphate ()
Qualaquin ()
Quinate ()
Quinine, sulfate (2:1) (salt) ()
FEMA NO. 2977 ()
Gls 1200 ()
Chininum sulphuricum ()
GLS1200 ()
NSC-757298 ()
Anhydrous quinine sulfate ()
Quinine sulfate anhydrous ()
Quinine sulfate hydrate ()
Quinine sulfate (2:1) ()
NSC-5362 ()
Quinine sulfate dihydrate ()
Quinine sulfate ()
Quinine hydrochloride anhydrous ()
Quinine monohydrochloride ()
Quinini hydrochloridum ()
FEMA NO. 2976 ()
Quinine hcl ()
Quinine hydrochloride hydrate ()
Chininum muriaticum ()
FEMA NO. 2976, DIHYDRATE- ()
Anhydrous quinine hydrochloride ()
Quinine hydrochloride dihydrate ()
Quinine muriate ()
QUININE HYDROCHLORIDE ()
FEMA NO. 2975 ()
Quinine bisulfate heptahydrate ()
Anhydrous quinine bisulfate ()
Quinine, sulfate (1:1) (salt) ()
Quinine bisulfate anhydrous ()
Quinine hydrogen sulfate ()
Quinini bisulfas ()
Quinine bisulphate heptahydrate ()
Biquinate ()
QUININE BISULFATE ()
Acid quinine hydrochloride ()
Neutral quinine hydrochloride ()
Quinini dihydrochloridum ()
Anhydrous quinine hydrobromide ()
Quinine, monohydrobromide ()
Quinine hydrobromide monohydrate ()
Quinine hbr ()
Quinine, monohbr ()
Quinine hydrobromide anhydrous ()
QUININE HYDROBROMIDE ()
Quinine, monosalicylate ()
Chininum salicylicum ()
QUININE SALICYLATE ()
Kineurine ()
QUININE GLYCEROPHOSPHATE ()
Quinine, phosphate (3:2) (salt) ()
Quinine phosphate, anhydrous ()
QUININE PHOSPHATE ()
Quinine biascorbate ()
QUININE ASCORBATE ()
P&D ID
PD010011
CAS
130-95-0
60-93-5
1407-83-6
72402-53-0
750-90-3
6119-47-7
Tags
natural product
drug
drug candidate
available
Approved by
FDA
First approval
2005
Drug indication
Antimalarial
Antimalarial,Deterrent (smoking)
Malaria
Deterrent (smoking)
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesised in the laboratory
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesised in the laboratory.
Quinine is one of the key antimalarial drugs listed in the WHO 20th Essential Medicines List (2017).
DESCRIPTION Extracted from the bark of the cinchona tree, quinine has also been synthesized in the laboratory .
DESCRIPTION First extracted from the bark of the cinchona tree and used as an antimalarial medicine, quinine has also been synthesized in the laboratory .

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
Cell lines
4
Organisms
3
Compound Sets
25
Cayman Chemical Bioactives
23958
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL170
CHEMBL2359966
CHEMBL2146088
CHEMBL2146083
CHEMBL588046
ChEMBL Drugs
CHEMBL170
CHEMBL2359966
CHEMBL2146088
CHEMBL2146083
CHEMBL588046
CHEMBL2146105
CHEMBL2146084
CHEMBL3707252
CHEMBL3707329
CHEMBL3707332
Concise Guide to Pharmacology 2017/18
2510
Concise Guide to Pharmacology 2019/20
2510
Concise Guide to Pharmacology 2021/22
2510
Concise Guide to Pharmacology 2023/24
2510
Drug Repurposing Hub
DrugBank
DB00468
DrugBank Approved Drugs
DB00468
DrugCentral
4523
DrugCentral Approved Drugs
4523
DrugMAP
DMSWYF5
DrugMAP Approved Drugs
DMSWYF5
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101583
Guide to Pharmacology
2510
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL170
MedChem Express Bioactive Compound Library
HY-B0433A
NCATS Inxight Approved Drugs
A7V27PHC7A
NPC Screening Collection
ReFrame library
Selleckchem Bioactive Compound Library
Quinine-hydrochloride-dihydrate
quinine
TargetMol Bioactive Compound Library
T0690
T4333
External IDs
141
Properties
(calculated by RDKit )
Molecular Weight
324.18
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
5
Aromatic Ring Count
2
cLogP
3.17
TPSA
45.59
Fraction CSP3
0.45
Chiral centers
5.0
Largest ring
6.0
QED
0.88
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Unknown molecular target
hemozoin biocrystallization inhibitor
Target
Ferriprotoporphyrin IX
Fe(II)-protoporphyrin IX
Platelet glycoprotein IX
Potassium Channel
GP9, KCNB2, KCNN4, SLC29A4
Dengue virus
Flavivirus
Parasite
Pathway
Membrane Transporter/Ion Channel
Anti-infection
Indication
malaria
Therapeutic Class
Antimalarials
Source data