General
Preferred name
CHLORAMPHENICOL
Synonyms
Chloromycetin ()
Chlornitromycin ()
Levomycetin ()
Mychel-S ()
Brochlor ()
Ophthochlor ()
Chlorbiotic ()
Brolene Antibiotic ()
Chloroptic S.O.P. ()
9-hydroxy-9-phenylxanthene ()
Tubilux Infected Eyes ()
Tevcocin ()
Kernispray ()
Amphicol ()
Xanthen-9-ol, 9-phenyl- ()
Econochlor ()
Golden Eye Antibiotic ()
NSC-16331 ()
Mychel ()
NSC-3069 ()
Chlorofair ()
Sno Phenicol ()
Kemicetine ()
Chloramex ()
Chloroptic ()
9-phenyl-9h-xanthen-9-ol ()
Optomycin ()
Klorafect ()
Chloramphenicol ()
P&D ID
PD010022
CAS
56-75-7
2787-09-9
137731-90-9
Tags
natural product
drug
available
Approved by
FDA
First approval
1950
Drug indication
Antibacterial
Bacterial infection
Antirickettsial
Drug Status
vet_approved
approved
withdrawn
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Chloramphenicol is a semisynthetic, broad-spectrum antibacterial derived from Streptomyces venequelae. Its activity is primarily bacteriostatic. (GtoPdb)
Cell lines
0
Organisms
15
Compound Sets
19
AdooQ Bioactive Compound Library
A10200
ChEMBL Approved Drugs
CHEMBL130
ChEMBL Drugs
CHEMBL130
Concise Guide to Pharmacology 2023/24
10901
Drug Repurposing Hub
DrugBank
DB00446
DrugBank Approved Drugs
DB00446
DrugCentral
589
DrugCentral Approved Drugs
589
DrugMAP
DMFXEWT
DrugMAP Approved Drugs
DMFXEWT
Enamine BioReference Compounds
Guide to Pharmacology
10901
MedChem Express Bioactive Compound Library
HY-B0239
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Chloramphenicol(Chloromycetin)
TargetMol Bioactive Compound Library
T1205
External IDs
51
Properties
(calculated by RDKit )
Molecular Weight
322.01
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
1
Aromatic Ring Count
1
cLogP
0.91
TPSA
112.7
Fraction CSP3
0.36
Chiral centers
2.0
Largest ring
6.0
QED
0.41
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Microbiology&virology
Anti-infection
Apoptosis
Autophagy
MAPK/ERK Pathway
Metabolic Enzyme/Protease
PI3K/Akt/mTOR
Protein Tyrosine Kinase/RTK
Target
50S ribosome
CD55
Akt
antibiotic
Bacterial
Beclin1
HIF/HIF Prolyl-Hydroxylase
JNK
MMP
VEGFR
Antibiotics for Plant Cell Culture,Bacterial,Selection Antibiotics for Transfected Cell
Indication
meningitis, fever, cholera
Disease Area
infectious disease, endocrinology
MOA
bacterial 50S ribosomal subunit inhibitor
Therapeutic Class
Antibiotics
Source data