General
Preferred name
betamethasone
Synonyms
Betamethasone (hydrochloride) ()
NSC-39470 ()
Betamethasone (Celestone) ()
Betamethasone hydrochloride ()
NSC-39470, SCH-4831 ()
Alphatrex ()
Betasolan ()
SCH 4831 ()
SCH-4831 ()
Uticort ()
Lotrisone ()
VISUBETA ()
Beta-Val ()
Taclonex ()
Betatrex ()
Flubenisolone ()
Dermabet ()
Celestone ()
Betnelan ()
P&D ID
PD010025
CAS
378-44-9
956901-32-9
Tags
available
drug
probe
Approved by
FDA
First approval
1961
Drug indication
Glucocorticoid
Inflammation
Drug Status
vet_approved
approved
Max Phase
4.0
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
Probe sources
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
32
No orthogonal probes found
Similar probes
3
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Marketed medications may contain dipropionate (eg Diprosone® and Diprolene®), sodium phosphate (eg Bentelan®) or valerate (eg Betnovate® and Celestone®) formulations.
(GtoPdb)
DESCRIPTION
Betamethasone hydrochloride is the hydrochloride of betamethasone, which is a synthetic corticosteroid and agonist of glucocorticoid receptor. It does not cause water retention. It has shown the inflammatory response by the betamethasone-receptor complex modulated the activity of certain genes, altering the production and activity of proteins. It has also revealed to inhibit keratinocyte proliferation. It has anti-inflammatory and immunosuppressive properties.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
2
Organisms
1
Compound Sets
30
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
High-quality chemical probes
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
NPC Screening Collection
Other bioactive compounds
Prestwick Chemical Library
Probe Miner (suitable probes)
ReFrame library
Selleckchem Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
44
Molecular Weight
392.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
0
cLogP
1.9
TPSA
94.83
Fraction CSP3
0.73
Chiral centers
8.0
Largest ring
6.0
QED
0.67
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Glucocorticoid Receptor
NR3C1
Pathway
GPCR/G protein
Apoptosis
Immunology/Inflammation
Vitamin D Related/Nuclear Receptor
Indication
corticosteroid-responsive dermatoses
MOA
Glucocorticoid Receptor agonist
Therapeutic Class
Antiinflammatory Agents
Solubility
10 mM in DMSO
Source data
