General
Preferred name
TRIMIPRAMINE
Synonyms
TRIMIPRAMINE MALEATE ()
Surmontil maleate ()
Trimipramine (maleate) ()
Trimipramine maleate salt ()
Trimipramine-d3 (maleate) ()
NSC-758386 ()
Surmontil ()
Stangyl ()
7162 RP ()
Trimeproprimine ()
IL 6001 ()
7162-RP ()
IL-6001 ()
P&D ID
PD010056
CAS
521-78-8
739-71-9
3564-75-8
3564-66-7
Tags
natural product
drug
nuisance
available
Approved by
FDA
First approval
1979
Drug indication
Major depressive disorder
Antidepressant
Drug Status
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Trimipramine is a tricyclic antidepressant (TCA) with antidepressant, anxiolytic, antipsychotic and sedative effects. Trimipramine is a racemic compound of two enantiomers; (S)-trimipramine and (R)-trimipramine. We show the non-stereo structure to represent the mixture.
Marketed formulations may contain trimipramine maleate (PubChem CID 5282318). (GtoPdb)
DESCRIPTION Serotonin reuptake inhibitor that also blocks norepinephrine reuptake; antidepressant (LOPAC library)
DESCRIPTION Trimipramine Maleate is a tricyclic antidepressant for the treatment of depression and depression accompanied by anxiety. (BOC Sciences Bioactive Compounds)
DESCRIPTION Trimipramine is a tricyclic antidepressant. It is serotonin and norepinephrine transport inhibitor with antipsychotic and sedative properties. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
23
BOC Sciences Bioactive Compounds
trimipramine-maleate-cas-521-78-8-314133
trimipramine-cas-739-71-9-item-76198
Cayman Chemical Bioactives
15921
31919
ChEMBL Approved Drugs
CHEMBL1200948
CHEMBL644
ChEMBL Drugs
CHEMBL1200948
CHEMBL644
DrugBank
DB00726
DrugBank Approved Drugs
DB00726
DrugCentral
2758
DrugCentral Approved Drugs
2758
DrugMAP
DM1SC8M
DrugMAP Approved Drugs
DM1SC8M
DrugMatrix
Guide to Pharmacology
7317
Ki Database
Trimipramine
LOPAC library
MedChem Express Bioactive Compound Library
HY-B1213
NCATS Inxight Approved Drugs
6S082C9NDT
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
trimipramine-maleate
TargetMol Bioactive Compound Library
T1045
The Spectrum Collection
External IDs
71
Properties
(calculated by RDKit )
Molecular Weight
294.21
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
4.12
TPSA
6.48
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
7.0
QED
0.84
Structural alerts
1
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
Pathway
GPCR/G protein
Neuroscience
Immunology/Inflammation
Anti-infection
Neuronal Signaling
Target
5-HT
Sert (Sodium-dependent)
Adrenergic Receptor
DA transporter
dopamine
H1 receptor
Noradrenaline transporter (Sodium-dependent)
5-HT Receptor
Bacterial
Therapeutic Class
Antidepressants
Solubility
Soluble in DMSO
Soluble in Chloroform (Slightly), Methanol (Slightly)
Source data