General
Preferred name
paroxetine
Synonyms
PAROXETINE HYDROCHLORIDE ()
Paroxetine hydrochloride hemihydrate (MW = 374.83) ()
Paroxetine maleate ()
BRL29060A ()
BRL29060 hydrochloride ()
Paroxetine HCl ()
FG-7051 ()
Paroxetine (HCl) ()
BRL29060 ()
BRL29060 (hydrochloride) ()
[3H]paroxetine ()
Paroxetine (hydrochloride) ()
PAROXETINE MESYLATE ()
Paroxetine hydrochloride hemihydrate ()
BRL-29060A, FG-7051 ()
BRL-29060A mesylate,FG-7051 mesylate ()
Paroxetine-d6 (hydrochloride) ()
Paroxetine hydrochloride anhydrous ()
Seroxat ()
Paxil Cr ()
Paxil ()
NSC-758654 ()
Parogen ()
Xetanor ()
Motivan ()
(-)3s,4r-paroxetine ()
Besitram ()
BRL 29060 ()
Paxpar ()
Daparox ()
Arotin ()
BRL-29060 ()
Frosinor ()
Casbol ()
Arketis ()
Pexeva ()
Paroxetine ()
POT.MES ()
Brisdelle ()
Paroxetine methanesulfonate ()
PO-T.MES ()
Paroxetine mesilate ()
Paroxetine methanesulphonate ()
Mesafem ()
[3H]-Paroxetine ()
[3H]PAROXETINE ()
P&D ID
PD010063
CAS
78246-49-8
61869-08-7
64006-44-6
110429-35-1
217797-14-3
Tags
available
drug
nuisance
Approved by
FDA
First approval
2003
1992
Drug indication
Depression
Antidepressant
Drug Status
investigational
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Paroxetine is a selective serotonin-reuptake inhibitor (SSRI) antidepressant. An X-ray structure of crystals of paroxetine bound SERT, shows a single central binding site (see PDB entry 5I6X).. (GtoPdb)
DESCRIPTION Potent inhibitor of vesicular monoamine transport (Tocris Bioactive Compound Library)
DESCRIPTION Selective serotonin reuptake inhibitor; antidepressant;Sold with permission of GlaxoSmithKline.;Actual molecular weight = 374.83 to account for 1/2 mole of water. (LOPAC library)
DESCRIPTION Highly potent and selective 5-HT uptake inhibitor (Tocriscreen Total)
DESCRIPTION Paroxetine hydrochloride hemihydrate is a antidepressant agents known as selective serotonin-reuptake inhibitors (SSRIs). (BOC Sciences Bioactive Compounds)
DESCRIPTION Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki = 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. (BOC Sciences Bioactive Compounds)
Cell lines
0
Organisms
7
Compound Sets
33
AdooQ Bioactive Compound Library
A11904
BOC Sciences Bioactive Compounds
paroxetine-maleate-cas-64006-44-6-item-74178
paroxetine-hydrochloride-hemihydrate-cas-110429-35-1-54362
Cayman Chemical Bioactives
14998
35603
ChEMBL Approved Drugs
CHEMBL1708
CHEMBL490
CHEMBL1200609
ChEMBL Drugs
CHEMBL1708
CHEMBL490
CHEMBL1200609
Concise Guide to Pharmacology 2017/18
4790
4561
Concise Guide to Pharmacology 2019/20
4790
4561
Concise Guide to Pharmacology 2021/22
4790
4561
Concise Guide to Pharmacology 2023/24
4790
4561
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00715
DrugBank Approved Drugs
DB00715
DrugCentral
2068
DrugCentral Approved Drugs
2068
DrugMAP
DM5PVQE
DrugMAP Approved Drugs
DM5PVQE
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101651
Guide to Pharmacology
4790
4561
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL490
MedChem Express Bioactive Compound Library
HY-B0492
HY-122272
NCATS Inxight Approved Drugs
41VRH5220H
NIH Clinical Collections (NCC)
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
Selleckchem Bioactive Compound Library
paroxetine-hcl
paroxetine-mesylate
TargetMol Bioactive Compound Library
T1636
The Spectrum Collection
Tocris Bioactive Compound Library
2141
Tocriscreen Total
External IDs
134
Properties
(calculated by RDKit )
Molecular Weight
329.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
3.33
TPSA
39.72
Fraction CSP3
0.37
Chiral centers
2.0
Largest ring
6.0
QED
0.93
Structural alerts
1
CAD
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Reuptake
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Autophagy
Target
5-HT
AChR
GRK2
CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HTR2A, SLC6A2, SLC6A4
Adrenergic Receptor
Serotonin Transporter
Primary Target
5-HT Transporters
MOA
Inhibitor
selective serotonin reuptake inhibitor (SSRI)
Indication
depression, obsessive compulsive disorder (OCD), generalized anxiety disorder (GAD), panic disorders, posttraumatic stress disorder, social anxiety disorder
Therapeutic Class
Antidepressants
Source data