General
Preferred name
apomorphine
Synonyms
(R)-(-)-Apomorphine hydrochloride ()
R(-) Apomorphine hydrochloride hemihydrate ()
Apomorphine SL ()
R-(???)-Apomorphine hydrochloride hemihydrate ()
Apomorphine hydrochloride hemihydrate ()
(-)-Apomorphine (hydrochloride hydrate) ()
(?)-Apomorphine (hydrochloride) ()
Apokyn ()
Euphorin ()
Bromophin ()
Apomorphine HCl ()
APOMORPHINE HYDROCHLORIDE ()
6a.beta.-aporphine-10,11-diol ()
APL-130277 ()
Apomorphinum ()
VR040 ()
VR-040 ()
Diaphine ()
APO-go PEN ()
Kw-6500 ()
Dacepton ()
Diamorph HCl ()
Apomorphinum muriaticum ()
APO-go ()
Apomorph hcl ()
Uprima ()
Kynmobi ()
Apomorphine hydrochloride hydrate ()
NSC-755875 ()
Diamorph,cocaine,chlorpromazine ()
Britaject ()
Ixense ()
Diamorph Roche ()
APO-go PFS ()
Taluvian ()
Diagesil ()
NSC-11442 ()
Apomine ()
Diamorphine hydrochloride ()
Apokinon ()
P&D ID
PD010064
CAS
314-19-2
41372-20-7
58-00-4
58117-94-5
Tags
natural product
drug
drug candidate
biased GPCR ligand
obsolete probe
available
Approved by
FDA
First approval
2004
2001
Drug indication
Emetic
Discovery agent
Idiopathic parkinson disease
Sexual dysfunction
Parkinson disease
Drug Status
investigational
withdrawn
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Apomorphine hydrochloride is a potent dopamine-receptor agonist. (GtoPdb)
DESCRIPTION Dopamine agonist; non-subtype-selective (Tocriscreen Total)
DESCRIPTION D1-like partial agonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
28
BiasDB
Apomorphine
Cayman Chemical Bioactives
34222
16094
ChEMBL Approved Drugs
CHEMBL53
CHEMBL5314363
ChEMBL Drugs
CHEMBL53
CHEMBL5314363
Concise Guide to Pharmacology 2017/18
33
Concise Guide to Pharmacology 2019/20
33
Concise Guide to Pharmacology 2021/22
33
Concise Guide to Pharmacology 2023/24
33
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00714
DrugBank Approved Drugs
DB00714
DrugCentral
228
DrugCentral Approved Drugs
228
DrugMAP
DMPH7EO
DMX38HQ
DrugMAP Approved Drugs
DMX38HQ
Guide to Pharmacology
33
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL53
NCATS Inxight Approved Drugs
N21FAR7B4S
NPC Screening Collection
Obsolete Compounds
apomorphine
Other bioactive compounds
Prestwick Chemical Library
ReFrame library
Tocris Bioactive Compound Library
2073
Tocriscreen Total
Withdrawn 2.0
EMA3
ZINC Tool Compounds
ZINC000000009073
External IDs
92
Properties
(calculated by RDKit )
Molecular Weight
267.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
2
cLogP
2.85
TPSA
43.7
Fraction CSP3
0.29
Chiral centers
1.0
Largest ring
6.0
QED
0.72
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Non-selective Dopamine
MOA
Agonist
Dopamine Receptor agonist
Target
ADRA2A, ADRA2B, ADRA2C, CALY, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B, HTR2C, HTR5A
Indication
Parkinson's Disease
ATC
G04BE07
N04BC07
Source data