General
Preferred name
naltrexone
Synonyms
Naltrexone HCl ()
Depade ()
Trexan ()
Antaxone ()
NALTREXONE HYDROCHLORIDE ()
Naltrexone hydrochloride dihydrate ()
ReVia ()
PTI-901 ()
Naltrexone (hydrochloride) ()
Naltrexone-d3 (CRM) ()
Naltrexone-d3 ()
Celupan ()
Vivitrol ()
NSC-758439 ()
EN-1639A FREE BASE ()
Trexal ()
EN-1639A ()
EN-1639A [As Hydrochloride] ()
EN-1639A (AS HYDROCHLORIDE) ()
Opizone ()
Adepend ()
Nalorex ()
ADEPEND ()
NALOREX ()
OPIZONE ()
P&D ID
PD010071
CAS
16676-29-2
16590-41-3
1261080-26-5
Tags
natural product
drug
available
Approved by
FDA
First approval
1984
Drug indication
Human immunodeficiency virus infection
Alcohol dependence
Antagonist (to narcotics)
Drug Status
investigational
vet_approved
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION This is the active isomer of naltrexone. The (+) isomer is inactive at the opioid receptors. (GtoPdb)
DESCRIPTION Potent melatonin agonist (Tocris Bioactive Compound Library)
Cell lines
0
Organisms
2
Compound Sets
32
AdooQ Bioactive Compound Library
A11723
Axon Medchem Screening Library
2416
Cayman Chemical Bioactives
15520
18325
19323
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL19019
CHEMBL1201149
ChEMBL Drugs
CHEMBL19019
CHEMBL1201149
Concise Guide to Pharmacology 2017/18
1639
Concise Guide to Pharmacology 2019/20
1639
Concise Guide to Pharmacology 2021/22
1639
Concise Guide to Pharmacology 2023/24
1639
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00704
DrugBank Approved Drugs
DB00704
DrugCentral
1765
DrugCentral Approved Drugs
1765
DrugMAP
DMUL45H
DrugMAP Approved Drugs
DMUL45H
Enamine BioReference Compounds
EUbOPEN Chemogenomics Library
Guide to Pharmacology
1639
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL19019
Natural product-based probes and drugs
NCATS Inxight Approved Drugs
5S6W795CQM
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
naltrexone-hcl
TargetMol Bioactive Compound Library
T0963
Tocris Bioactive Compound Library
0677
ZINC Tool Compounds
ZINC000000001773
External IDs
78
Properties
(calculated by RDKit )
Molecular Weight
341.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
1
cLogP
1.53
TPSA
70.0
Fraction CSP3
0.65
Chiral centers
4.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
Opioid Receptor antagonist
Antagonist
Target
Opioid receptors
mu/kappa/delta
Opioid Receptor
OPRD1, OPRK1, OPRM1, SIGMAR1
Opioid antagonist
Pathway
Endocrinology/Hormones
GPCR/G protein
Neuroscience
Primary Target
Miscellaneous Opioids
Indication
abstinence from alcohol
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Antinarcotic
Therapeutic Class
CNS & PNS
Recommended Cell Concentration
None
Source data