General
Preferred name
AMPRENAVIR
Synonyms
VX-478 ()
141W94 ()
KVX-478 ()
Prozei ()
Amprenavir ()
Amprenavir (VX-478) ()
141W94, VX-478, KVX-478 ()
J05AE05 ()
141 W94 ()
Agenerase ()
Amprenavir-d4 ()
P&D ID
PD010072
CAS
161814-49-9
2738376-78-6
Tags
available
drug
Approved by
FDA
EMA
First approval
1999
Drug indication
Human immunodeficiency virus infection
Drug Status
approved
withdrawn
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Amprenavir is an anti-HIV-1 agent. It inhibits the viral protease. (GtoPdb)
Cell lines
2
Organisms
5
Compound Sets
25
AdooQ Bioactive Compound Library
A11985
Cayman Chemical Bioactives
15369
28703
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL116
ChEMBL Drugs
CHEMBL116
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DB00701
DrugBank Approved Drugs
DB00701
DrugCentral
200
DrugCentral Approved Drugs
200
DrugMAP
DMLMXE0
DrugMAP Approved Drugs
DMLMXE0
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS100151
Guide to Pharmacology
12681
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL116
MedChem Express Bioactive Compound Library
HY-17430
NCATS Inxight Approved Drugs
5S0W860XNR
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
Amprenavir-(Agenerase)
TargetMol Bioactive Compound Library
T6388
Withdrawn 2.0
837
External IDs
48
Properties
(calculated by RDKit )
Molecular Weight
505.22
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
11
Ring Count
3
Aromatic Ring Count
2
cLogP
2.4
TPSA
131.19
Fraction CSP3
0.48
Chiral centers
3.0
Largest ring
6.0
QED
0.4
Structural alerts
1
aggregator (ZINC)
Aggregators
Related compounds
Custom attributes
(extracted from source data)
MOA
viral protease inhibitor
HIV Protease inhibitor
Target
Human immunodeficiency virus type 1 protease
HIV Protease
HIV
SARS-CoV
Pathway
Microbiology&virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Indication
human immunodeficiency virus (HIV-1)
ATC
J05AE05
Therapeutic Class
Anti-HIV Agents
Source data