General
Preferred name
profenamine
Synonyms
ETHOPROPAZINE HYDROCHLORIDE ()
Isothazine (hydrochloride) ()
Lysivane (hydrochloride) ()
Parsidol (hydrochloride) ()
Profenamine hydrochloride ()
ETHOPROPAZINE ()
Ethopropazine (hydrochloride) ()
Prophenamine hydrochloride ()
Ethopropazine hcl ()
NSC-169467 ()
NSC-64074 ()
Profenamine Hibenzate ()
Parsidol ()
Profenamina ()
P&D ID
PD010074
CAS
1094-08-2
522-00-9
42957-54-0
Tags
available
drug
Approved by
FDA
Drug indication
Parkinson disease
Antiparkinsonian
Drug Status
approved
withdrawn
Max Phase
4.0
First approval
1982
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Ethopropazine is a phenothiazine derivative drug.
(GtoPdb)
DESCRIPTION
Butyrylcholinesterase inhibitor; antiparkinsonian
(LOPAC library)
DESCRIPTION
Ethopropazine hydrochloride is an inhibitor of butyrylcholinesterase. It is a medication derived from phenothiazine. It could reduce extrapyramidal motor effects and used as an antidyskinetic to treat Parkinson's disease. It also alleviates thermal hyperalgesia in rats. It is sold under the trade names Parsidol in the United States and Parsidan in Canada. It was developed by Pfizer and has been listed.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
22
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
Ki Database
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
The Spectrum Collection
Withdrawn 2.0
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
45
Molecular Weight
312.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
5
Ring Count
3
Aromatic Ring Count
2
cLogP
5.02
TPSA
6.48
Fraction CSP3
0.37
Chiral centers
1.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Butyrylcholinesterase
Member status
member
MOA
NMDA Antagonists
Butyrylcholinesterase Inhibitors
ATC
N04AA05
Pathway
Neuronal Signaling
Therapeutic Class
Antiparkinson Agents
Target
Cholinesterase (ChE)
Solubility
DMSO: >5 mg/mL at ~60 °C, clear
Source data
