General
Preferred name
CLOBAZAM
Synonyms
Clobazam - Lundbeck ()
HR-376 ()
LM-2717 ()
Colbazam ()
Mystan ()
Urbanyl ()
H 4723 ()
HR 376 ()
LM 2717 ()
NSC-336279 ()
Perizam ()
Frisium ()
Sympazan ()
Onfi ()
H-4723 ()
Urbadan ()
Tapclob ()
P&D ID
PD010087
CAS
22316-47-8
Tags
natural product
drug
available
Approved by
FDA
First approval
2011
2005
Drug indication
Epilepsy
Tranquilizer (minor)
Anxiety disorder
Drug Status
illicit
approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
METABOLISM Clobazam is extensively metabolized in the liver via N-demethylation and hydroxylation to form two major metabolites, N-desmethylclobazam (norclobazam) and 4'-hydroxyclobazam, respectively. N-desmethylclobazam (norclobazam) retains pharmacological activity. Norclobazam is one-fourth the potency of clobazam. The main enzyme that facilitates the process of N-demethylation is CYP3A4, and to a lesser extent by CYP2C19 and CYP2B6. Norclobazam itself is also metabolized via hydroxylation, primarily by CYP2C19. The formation of 4'-hydroxyclobazam is facilitated by CYP2C18 and CYP2C19. A factor in determining extent of metabolism is the genetic profile of the individual patient as CYP2C19 is a polymorphic enzyme.
ABSORPTION After oral administration of clobazam, it is almost completely absorbed (87% of dose). Bioavailability relative to solution was almost at 100%. Food does not affect absorption. ; Tmax = 1-3 hours.
DESCRIPTION Clobazam is a benzodiazepine drug. (GtoPdb)
Compound Sets
15
Cayman Chemical Bioactives
14262
ChEMBL Approved Drugs
CHEMBL70418
ChEMBL Drugs
CHEMBL70418
DrugBank
DB00349
DrugBank Approved Drugs
DB00349
DrugCentral
682
DrugCentral Approved Drugs
682
DrugMAP
DMW1OQ0
DrugMAP Approved Drugs
DMW1OQ0
DrugMatrix
Guide to Pharmacology
7149
Ki Database
Clobazam
NCATS Inxight Approved Drugs
2MRO291B4U
NPC Screening Collection
ReFrame library
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
300.07
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
2
cLogP
3.37
TPSA
40.62
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
7.0
QED
0.76
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Therapeutic Class
Neurology Agents
Source data