General
Preferred name
DOXYLAMINE
Synonyms
DOXYLAMINE SUCCINATE ()
Doxylamine chlorotheophyllinate ()
Doxylamine (D5 succinate) ()
Decapryn ()
NSC-74772 ()
Hoggar n ()
Doxylamine hydrogen succinate ()
Donormyl ()
Doxy-Sleep-Aid ()
Alsodorm ()
Meraprina ()
Dormidina ()
Gittalun ()
Unisom ()
Donormil ()
Doxilamina ()
Doxylamine (succinate) ()
Doxylamine-d5 (succinate) ()
P&D ID
PD010224
CAS
562-10-7
469-21-6
1216840-94-6
Tags
available
drug
Approved by
FDA
First approval
1948
Drug indication
Antihistaminic
Morning sickness
Drug Status
approved
withdrawn
vet_approved
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Doxylamine is an antihistamine. (GtoPdb)
DESCRIPTION H1 Histamine receptor antagonist (LOPAC library)
Cell lines
0
Organisms
1
Compound Sets
22
Cayman Chemical Bioactives
21826
40674
ChEMBL Approved Drugs
CHEMBL1200392
CHEMBL1004
ChEMBL Drugs
CHEMBL1200392
CHEMBL1004
Drug Repurposing Hub
DrugBank
DB00366
DrugBank Approved Drugs
DB00366
DrugCentral
962
DrugCentral Approved Drugs
962
DrugMAP
DMKOXFE
DrugMAP Approved Drugs
DMKOXFE
Enamine BioReference Compounds
Guide to Pharmacology
7171
LOPAC library
NCATS Inxight Approved Drugs
95QB77JKPL
NIH Clinical Collections (NCC)
NPC Screening Collection
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
doxylamine-succinate
TargetMol Bioactive Compound Library
T1115
The Spectrum Collection
Withdrawn 2.0
w245
External IDs
58
Properties
(calculated by RDKit )
Molecular Weight
270.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
2
cLogP
2.92
TPSA
25.36
Fraction CSP3
0.35
Chiral centers
1.0
Largest ring
6.0
QED
0.81
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
H1
Target
Histamine Receptor
H1 receptor
HRH1
Pathway
Immunology/Inflammation
GPCR/G protein
Neuronal Signaling
Neuroscience
Indication
sedative
MOA
Histamine Receptor antagonist
ATC
R06AA59
R06AA09
Toxicity type
reproductive
Therapeutic Class
Hypnotics and Sedatives
Source data