General
Preferred name
biotin
Synonyms
Vitamin H ()
Vitamin B7 ()
D-Biotin ()
Biotin (Vitamin B7) ()
Bioepiderm ()
Ritatin ()
NSC-63865 ()
Biotin 100 ()
MD-1003 ()
P&D ID
PD010231
CAS
58-85-5
15720-24-8
56846-45-8
Tags
natural product
drug
nuisance
available
Approved by
FDA
First approval
1953
1985
Drug indication
Discovery agent
Vitamin
Drug Status
investigational
approved
nutraceutical
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PHARMACODYNAMICS Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring, which attaches a valeric acid substituent at one of its carbon atoms. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; changes in mental status, generalized muscular pains (myalgias), hyperesthesias and paresthesias. The treatment for biotin deficiency is to simply start taking some biotin supplements. A lack of biotin in infants will lead to a condition called seborrheic dermatitis or "cradle cap". Biotin deficiencies are extremely rare in adults but if it does occur, it will lead to anemia, depression, hair loss, high blood sugar levels, muscle pain, nausea, loss of appetite and inflamed mucous membranes.
DESCRIPTION Biotin is a water-soluble B-complex vitamin and is an essential co-factor in various metabolic chemical conversions involving biologic carboxylations and the transfer of carbon dioxide. Biotin is critical for cell growth, fatty acid production and fat and amino acid metabolism. Biotin is used as a nutritional supplement, and to correct dietary shortage or imbalance. (GtoPdb)
Cell lines
1
Organisms
0
Compound Sets
25
Cayman Chemical Bioactives
22582
ChEMBL Approved Drugs
CHEMBL857
ChEMBL Drugs
CHEMBL857
Concise Guide to Pharmacology 2017/18
4787
Concise Guide to Pharmacology 2019/20
4787
Concise Guide to Pharmacology 2021/22
4787
Concise Guide to Pharmacology 2023/24
4787
Drug Repurposing Hub
DrugBank
DB00121
DrugBank Approved Drugs
DB00121
DrugCentral
373
DrugCentral Approved Drugs
373
DrugMAP
DMKMCE1
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101683
Guide to Pharmacology
4787
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL857
MedChem Express Bioactive Compound Library
HY-B0511
NCATS Inxight Approved Drugs
6SO6U10H04
NPC Screening Collection
Nuisance compounds in cellular assays
Prestwick Chemical Library
ReFrame library
Selleckchem Bioactive Compound Library
biotin-vitamin-b7
TargetMol Bioactive Compound Library
T1116
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
244.09
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
0
cLogP
0.8
TPSA
78.43
Fraction CSP3
0.8
Chiral centers
3.0
Largest ring
5.0
QED
0.49
Structural alerts
1
Streptavidin-biotin disruption
Nuisance compounds in cellular assays
Related compounds
Custom attributes
(extracted from source data)
Pathway
Metabolism
Metabolic Enzyme/Protease
Target
VB7
ACACA, ACACB, HLCS, MCCC1, MCCC2, PC, PCCA, PCCB, SLC5A6
Endogenous Metabolite
Dyes,Vitamin
MOA
vitamin B
Source data