General
Preferred name
FH535
Synonyms
FH 535 ()
FH535 sodium salt ()
?-Catenin/Tcf Inhibitor, FH535 ()
P&D ID
PD010299
CAS
108409-83-2
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibitor of Wnt/beta-catenin signaling
(Tocriscreen Plus)
DESCRIPTION
Inhibits NOD1-induced NF-kappaB activation
(Tocris Bioactive Compound Library)
DESCRIPTION
FH535 is a Wnt/β-catenin signaling inhibitor. It was shown to inhibit proliferation and motility of various cancer stem cells including liver cancer stem cells and colon cancer cells.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
FH535 sodium salt is a dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, leading to the inhibition of proliferation and motility of multiple cancer cells.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
601
Organisms
0
Compound Sets
13
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
Welcome Trust Cancer Drugs
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
359.97
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
4.01
TPSA
89.31
Fraction CSP3
0.08
Chiral centers
0.0
Largest ring
6.0
QED
0.66
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Target
¦Â-catenin
PPAR??
Wnt/??-catenin
??catenin
PPARD, PPARG
Dual Wnt/ß-catenin and PPAR inhibitor
PPAR
Wnt
β-catenin
PPAR,Wnt/beta-catenin
Pathway
Cytoskeletal Signaling
Metabolism
Stem Cells
DNA Damage/DNA Repair
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Stem Cell/Wnt
Vitamin D Related/Nuclear Receptor
Primary Target
?-catenin
MOA
PPAR receptor antagonist, WNT signaling inhibitor
Source data
