General
Preferred name
OMECAMTIV MECARBIL
Synonyms
CK-1827452 ()
CK 1827452 ()
Omecamtiv mecarbil (CK-1827452) ()
Omecamtiv mecarbilo ()
P&D ID
PD010915
CAS
873697-71-3
Tags
available
drug candidate
Drug indication
Heart failure
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Omecamtiv mecarbil is an investigational small molecule which is a direct activator of cardiac myosin . This compound is being investigated as a novel therapy for patients with chronic heart failure due to systolic dysfunction. Results from the first-in-man study are reported by Teerlink et al. (2011) .
Omecamtiv mecarbil is claimed in patent US7507735 B2 . (GtoPdb)
Compound Sets
14
AdooQ Bioactive Compound Library
A11206
Axon Medchem Screening Library
1835
Cayman Chemical Bioactives
21074
ChEMBL Drugs
CHEMBL1800955
Drug Repurposing Hub
DrugBank
DB11816
DrugMAP
DM624TW
Guide to Pharmacology
8740
Mcule NIBR MoA Box Subset
MCULE-9121272903
MedChem Express Bioactive Compound Library
HY-14233
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Selleckchem Bioactive Compound Library
Omecamtiv-mecarbil-CK-1827452
TargetMol Bioactive Compound Library
T2006
External IDs
27
Properties
(calculated by RDKit )
Molecular Weight
401.19
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
3.06
TPSA
86.8
Fraction CSP3
0.35
Chiral centers
0.0
Largest ring
6.0
QED
0.82
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Membrane Transporter/Ion Channel
cytoskeleton
Target
ATPase
MYBPC3
Myosin activator
Myosin
Member status
member
MOA
Cardiac Myosin Activators
cardiac myosin activator
Source data