General
Preferred name
ABT-751
Synonyms
ABT 751 ()
E-7010 ()
E7010 ()
ABT751 ()
ABT-751 (E7010) ()
NSC-742134 ()
E 7010 ()
P&D ID
PD011108
CAS
141430-65-1
857447-92-8
Tags
available
nuisance
drug candidate
Drug indication
Solid tumour/cancer
Drug Status
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Inhibitor of microtubule polymerization; antimitotic and antitumor
(Tocriscreen Plus)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
30
Organisms
1
Compound Sets
15
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugMAP
DrugMatrix
LINCS compound set
MedChem Express Bioactive Compound Library
Nuisance compounds in cellular assays
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocriscreen Plus
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
371.09
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
3
Rotatable Bonds
6
Ring Count
3
Aromatic Ring Count
3
cLogP
3.34
TPSA
100.55
Fraction CSP3
0.06
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
1
Tubulin modulation
Nuisance compounds
Related compounds
Custom attributes
(extracted from source data)
Target Type
Cell Biology
Pathway
Cytoskeletal Signaling
Apoptosis
Autophagy
Cell Cycle/DNA Damage
cytoskeleton
Target
Microtubule
TUBB
Microtubule/Tubulin
Microtubule Associated
MOA
tubulin polymerization inhibitor
Source data
